- ￥2650
- LSM Bio
- 进口
- PAab05781
- 2025年07月13日
- ELISA,WB
- E. coli - derived recombinant protein
- Human, Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
nucleotide-binding oligomerization domain containing 2
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9WVH4
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
nucleotide-binding oligomerization domain containing 2
- 抗体英文名：
anti-NOD2 antibody,NOD2 antibody
- 抗体名：
anti-NOD2 抗体,NOD2 抗体
- 规格：
100μl
NOD2抗体| NOD2 antibody
货号 PAab05781
蛋白别名 CARD15 antibody, IBD1
蛋白介绍
Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).
产品描述
anti-NOD2 antibody is a Rabbit Polyclonal antibody againstNOD2..
建议稀释比例
IHC
Western blot
(本抗体仅供体外科研用途，不可用于临床诊断!) <"">
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文献和实验Polymorphisms Within Epithelial Receptors: NOD2/CARD15
) within the intracytoplasmatic receptor NOD2/CARD15, which recognizes the bacterial cell wall compound muramyl-dipeptide and induces nuclear factor-KB-mediated inflammation. By performing TaqMan PCR of the three major SNPs also identified as risk factors in Crohn’s disease
Cell-Based Reporter Assay to Analyze Activation of Nod1 and Nod2
Nod1 and Nod2 are pattern recognition receptors of the mammalian innate immune system. They respond to bacterial peptidoglycan fragments and are implicated in host defense against a variety of �different bacterial pathogens. Recent studies
TLR4 与 M-R 家族分子 NOD2 的相互作用 应该指出，对不同TLR家族成员启动的信号通路，参与的衔接蛋白和蛋白激酶可能不同。TLR4即是一例。首先，TI~R4结构有其特殊性。受体分子由同源二聚体TLR4-TLR4组成，一旁还结合有IL-14跨膜蛋白，并有一个称为MD2的分子参与。而且，该受体与配体LPS结合，往往通过前面提到的模式识别分子LBP。第二，TL4R信号途径还有MyD88依赖和不依赖两种。后者通过其他携带TlR结构域的衔接蛋白启动信号转导。因为只要有TlR
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