- ￥22
- ProSci
- 美国
- PSI-2511-0.02mg
- 2025年07月11日
- E, WB, ICC, IF
- 兔
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
NOD2 antibody was raised against a synthetic peptide corresponding to 16 amino acids at the amino terminus of human NOD2.<br>The immunogen is located within the first 50 amino acids of NOD2.
- 保存条件：
stored at 4℃ for three months and -20℃, stable for up to one year
- 保质期：
1年
- 级别：
科研级别
- 库存：
100
- 供应商：
艾美捷科技
- 宿主：
兔
- 应用范围：
E, WB, ICC, IF
- 抗体英文名：
NOD2 Antibody
- 抗体名：
NOD2 Antibody
- 规格：
0.02mg
NOD2 抗体，NOD2 Antibody，NOD2 抗体,NOD2 Antibody
产品名称：NOD2 抗体-NOD2 Antibody
产品货号：PSI-2511-0.02mg
产品规格：0.02mg
背景资料：NOD2 Antibody: Apaf-1 and NOD1 are members of a new family, which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD). A third member in this family was recently identified and designated NOD2. NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-κB, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn's disease that is a main type of chronic inflammatory bowel disease.
保存建议：NOD2 抗体-NOD2 Antibody stored at 4℃ for three months and -20℃, stable for up to one year
应用类型：E, WB, ICC, IF
点击：NOD2 抗体-NOD2 Antibody查看更详细产品说明，更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品中心。
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文献和实验Polymorphisms Within Epithelial Receptors: NOD2/CARD15
) within the intracytoplasmatic receptor NOD2/CARD15, which recognizes the bacterial cell wall compound muramyl-dipeptide and induces nuclear factor-KB-mediated inflammation. By performing TaqMan PCR of the three major SNPs also identified as risk factors in Crohn’s disease
Cell-Based Reporter Assay to Analyze Activation of Nod1 and Nod2
Nod1 and Nod2 are pattern recognition receptors of the mammalian innate immune system. They respond to bacterial peptidoglycan fragments and are implicated in host defense against a variety of �different bacterial pathogens. Recent studies
TLR4 与 M-R 家族分子 NOD2 的相互作用 应该指出，对不同TLR家族成员启动的信号通路，参与的衔接蛋白和蛋白激酶可能不同。TLR4即是一例。首先，TI~R4结构有其特殊性。受体分子由同源二聚体TLR4-TLR4组成，一旁还结合有IL-14跨膜蛋白，并有一个称为MD2的分子参与。而且，该受体与配体LPS结合，往往通过前面提到的模式识别分子LBP。第二，TL4R信号途径还有MyD88依赖和不依赖两种。后者通过其他携带TlR结构域的衔接蛋白启动信号转导。因为只要有TlR
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