- ￥2650
- LSM Bio
- 进口
- PAab05427
- 2025年07月17日
- ELISA,WB,FC,IHC,IP
- E. coli - derived recombinant protein
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
mucin 1, cell surface associated
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P15248
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,FC,IHC,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
mucin 1, cell surface associated
- 抗体英文名：
anti-MUC1 antibody,MUC1 antibody
- 抗体名：
anti-MUC1 抗体,MUC1 抗体
- 规格：
100μg
MUC1抗体| MUC1 antibody
货号 PAab05427
蛋白别名 PUM
蛋白介绍
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein- protein interactions. Modulates signaling in ERK, SRC and NF- kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
产品描述
anti-MUC1 antibody is a Rabbit Polyclonal antibody againstMUC1..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human lung cancer using PAab05427(CA15-3,MUC1 antibody) at dilution of 1:50
Western blot
A431 cells were subjected to SDS PAGE followed by western blot with PAab05427(CA15-3,MUC1 antibody) at dilution of 1:1500(本抗体仅供体外科研用途，不可用于临床诊断!) <"">
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文献和实验MUC1 Expression in Lung Cancer
Abnormalities in mucin-type glycoprotein expression have been documented in a variety of cancers, identifying these molecules as targets for immunologically based therapies and prognostic/diagnostic assays. Epithelial mucin proteins
MUC1 is normally apical in polarized epithelial cells but is aberrantly localized in tumor cells. To better understand the mechanism of this altered localization as well as the normal functions of MUC1, we are focused on characterizing
在免疫反应方面，基于抗原的刺激在体内形成、并与抗原作特异性结合的蛋白质之总称。其化学实质是免疫球蛋白。抗体，按照抗原抗体反应的类型可分别称为沉淀素、凝集素、溶血素、溶菌素、抗毒素、中和抗体等，但这些并不等于有相应的不同抗体存在，一般多只表明抗体反应的多样性而已。抗体在血清中含量最多（体液抗体=humoral antibody）；含有某特定抗体的血清称为抗血或免疫血清。
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