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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
HtrA serine peptidase 1
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
Polyclonal antibody
- 标记物:
Non-conjugated
- 适应物种:
Human,Mouse ,Rat
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
P15248
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA,WB,IF,IP,IHC
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
HtrA serine peptidase 1
- 抗体英文名:
anti-HTRA1 antibody,HTRA1 antibody
- 抗体名:
anti-HTRA1 抗体,HTRA1 抗体
- 规格:
100μg
HTRA1抗体| HTRA1 antibody
货号 PAab04069
蛋白别名 HTRA antibody, PRSS11
蛋白介绍
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
产品描述
anti-HTRA1 antibody is a Rabbit Polyclonal antibody againstHTRA1..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human placenta tissue slide using PAab04069( HTRA1 Antibody) at dilution of 1:200
Western blot
L02 cells were subjected to SDS PAGE followed by western blot with PAab04069(HTRA1 antibody) at dilution of 1:600(本抗体仅供体外科研用途,不可用于临床诊断!) <"">
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文献和实验人HtrA丝氨酸肽酶1 (Htra1)ELISA试剂盒 说明书
上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 人 HtrA丝氨酸肽酶 1 ( Htra1 )ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和其它生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗人 Htra1 单抗包被于酶标板上,标准品和样品中的 Htra1与单抗结合,加入
在免疫反应方面,基于抗原的刺激在体内形成、并与抗原作特异性结合的蛋白质之总称。其化学实质是免疫球蛋白。抗体,按照抗原抗体反应的类型可分别称为沉淀素、凝集素、溶血素、溶菌素、抗毒素、中和抗体等,但这些并不等于有相应的不同抗体存在,一般多只表明抗体反应的多样性而已。抗体在血清中含量最多(体液抗体=humoral antibody);含有某特定抗体的血清称为抗血或免疫血清。
机体在抗原物质刺激下,由B细胞分化成的浆细胞所产生的、可与相应抗原发生特异性结合反应的免疫球蛋白。因为最初有人用电泳证明血清中抗体活性在γ球蛋白部分,故曾把抗体统称为两种(γ)球蛋白。后来证明,抗体并不都在γ区;而且位于γ区的球蛋白,也不一定都具有抗体活性。1964年,世界卫生组织举行专门会议,将具有抗体活性以及与抗体相关的球蛋白统称为免疫球蛋白(Ig)。如骨髓瘤蛋白,巨球蛋白血症、冷球蛋白血症等患者血清中存在的异常免疫球蛋白以及“正常人”天然存在的免疫
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