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文献和实验【信息】The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
molecule) are recruited to TIR (Toll/interleukin-1 (IL-1) receptor) domains to initiate signalling, whereas SARM (sterile - and armadillo-motif-containing protein) inhibits TRIF-dependent signalling. MyD88 is the universal adaptor used by all TLRs
Bioinformatic Analysis of Toll-Like Receptor Sequences and Structures
. In the context of Toll-interleukin-1 receptor (TIR) domain containing proteins, we describe here a series of the more common and user-friendly bioinformatic tools available as internet-based resources. These will enable the identification and alignment of protein
, inhibitor of NFκ B; IRAK, IL-1R-associated kinase; LTA, lipoteichoic acid; NIK, NFκ B-inducing kinase; PGN, peptidoglycan; RIP, receptor-interacting protein; TNF, tumour necrosis factor; TNFR, TNF receptor; TRADD, TNFR1-associated protein with death domain
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