重组大鼠IL-21报价

特别提示：包括重组大鼠IL-21在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组大鼠IL-21
英文名称：Recombinant Rat Interleukin 21
产品货号：GS4576
产品规格：2μg

分子量：Approximately 15.2kDa,a single non-glycosylated polypeptide chain containing 129 amino acids.
储存条件：冷冻（-20℃）

概述

Rat IL-21 is produced by CD4+ T cells in response to antigenic stimulation and can regulating immune system cells,for instance cytotoxic T cells and natural killer cells.The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells,stimulation with IL-4 of IgG production,and induction of apoptotic effects in na?ve B-cells and stimulated B-cells in the absence of T-cell signaling.Additionally,it promotes the anti-tumor activity of CD8+ T-cells and NK cells.IL-21 elicits its effect through binding to IL-21R,which also contains the gamma chain found in other cytokine receptors such as IL-2,IL-4,IL-7,IL-9 and IL-15.IL-21 shows having much relation with clinical illnesses,including cancer immunotherapy,viral infections and allergies.Mature rat IL-21 shares 88%a.a.sequence identity with mouse IL-21.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞96%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using human N1186 cells is less than 50ng/ml,corresponding to a specific activity of>2.0×104 IU/mg.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rRtIL-21 as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	HKSSPQRPDH LLIRLRHLMD IVEQLKIYEN DLDPELLTAP QDVKGQCEHE AFACFQKAKL KPSNTGNNKT FINDLLAQLR RRLPAKRTGN KQRHMAKCPS CDLYEKKTPK EFLERLKWLL QKMIHQHLS

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