活性: Measured by its binding ability in a functional ELISA. Immobilized Human BCMA, Fc Tag (Cat. No. BC7-H5254) at 5 μg/mL (100 μL/well) can bind Human APRIL, His Tag (Cat. No. APL-H5244) with a linear range of 8-125 ng/mL (QC tested).
产品背景: APRIL(a proliferation-inducing ligand) is also known as Tumor necrosis factor ligand superfamily member 13, TALL-2, TRDL-1, CD256, TNFFSF 13, cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. APRIL is a cytokine of the tumor necrosis factor family associated mainly with hematologic malignancies. The closely related TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) serve in the generation and maintenance of mature B-lymphocytes. Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors that they partially share. BAFF-APRIL heteromers of different stoichiometries have distinct receptor-binding properties and activities. In addition, expression of APRIL was regulated by miR-145 in GC cells.
产品描述: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 22.8 kDa. The protein migrates as 28 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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