重组人PCSK9(C端His标签)北京现货

特别提示：包括重组人PCSK9(C端His标签)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人PCSK9(C端His标签)
英文名称：Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9
产品货号：JN0847
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Gln31-Gln692在C端含有His标签。

PCSK9质量控制：＞95%(还原性SDS-PAGE)

PCSK9制剂：液体

PCSK9保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于PCSK9：
Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9/PCSK9 (D374Y) is a gain of function mutant of human PCSK9 protein. Human PCSK9 is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER, the pro domain and mature chain are secreted together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and it plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.

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