重组人UBE2D3(带His标签)北京现货

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产品名称：重组人UBE2D3(带His标签)
英文名称：Recombinant Human Ubiquitin Conjugating Enzyme E2 D3, His
产品货号：GS4882
产品规格：10μg

分子量：Approximately 17.7kDa,a single non-glycosylated polypeptide chain containing 147 amino acids(a.a.)of human UBE2D3/UBC5C and 8 a.a.vector sequence including 6×His tag at N-terminus.
储存条件：冷冻（-20℃）

概述

Ubiquitin-conjugating enzyme E2 D3 belongs to the ubiquitin-conjugating enzyme family and is encoded by the UBE2D3 gene in humans.The ubiquitin-conjugating enzymes,also known as E2 enzymes and more rarely as ubiquitin-carrier enzymes,take part in the second step in the ubiquitination reaction.In this reaction,E1 activates the ubiquitin by covalently attaching the molecule to its active site cysteine residue.The activated ubiquitin is then transferred to an E2 cysteine and then the E2 molecule binds E3 via a structurally conserved binding region.The ubiquitination reaction can modify proteins and regulate protein degradation.The UBE2D3 is a human homolog of the yeast UBC4/5 family and play many important regulatory roles in inflammation and cancer.It mediates the degradation of a myriad of short-lived regulatory proteins(such as p53 in the presence of E6/E6-AP or MDM2,c-Fos,IκBα,p105)and abnormal proteins and has 88%and 89%sequence identity with UbcH5a and UbcH5b respectively.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Data is not available.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,1mMDTT,pH 7.5.
内毒素	Less than 1 EU/μg of rHuUBE2D3/UBC5C,His as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	MHHHHHHAMA LKRINKELSD LARDPPAQCS AGPVGDDMFH WQATIMGPND SPYQGGVFFL TIHFPTDYPF KPPKVAFTTR IYHPNINSNG SICLDILRSQ WSPALTISKV LLSICSLLCD PNPDDPLVPE IARIYKTDRD KYNRISREWT QKYAM

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