重组人PLA2G1B(IB型磷脂酶A2)

特别提示：包括重组人PLA2G1B(IB型磷脂酶A2)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人PLA2G1B(IB型磷脂酶A2)
英文名称：Recombinant Human Phospholipase A2 Group IB
产品货号：JN1286
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Ala23-Ser148在C端含有His标签。

PLA2G1B质量控制：＞95%(还原性SDS-PAGE)

PLA2G1B制剂：液体

PLA2G1B保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于PLA2G1B：
Phospholipase A2(PLA2G1B) is a secreted protein which belongs to the phospholipase A2 family. It catalyzes the release of fatty acids from glycero-3-phosphocholines. It catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. Sequences of pancreatic PLA2G1B enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Mice lacking in PLA2G1B are resistant to obesity and diabetes induced by feeding a diabetogenic high-fat/high-carbohydrate diet. Oral supplementation of a diabetogenic diet with the PLA2G1B inhibitor methyl indoxam effectively suppresses diet-induced obesity and diabetes. PLA2G1B inhibition may be a potentially effective oral therapeutic option for treatment of obesity and diabetes.

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