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Please store the product under the recommended conditions in the Certificate of Analysis.
- 英文名：
MW01-18-150SRM dihydrochloride dihydrate
- 库存：
货期：电询
- 供应商：
MedChemExpress LLC
- CAS号：
1661020-92-3
- 规格：
电询
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MW-150 dihydrochloride dihydrate
CAS No. : 1661020-92-3
MCE 国际站：MW-150 dihydrochloride dihydrate
产品活性：MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) 是一种选择性的，具有口服活性的，可透过神经系统的 p38α MAPK 抑制剂，Ki 值为 101 nM。MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) 抑制内源性 p38α MAPK 在活化的神经胶质中磷酸化内源性底物 MK2 的能力。
研究领域：MAPK/ERK Pathway | Autophagy
In Vitro: MW-150 dihydrochloride dihydrate inhibits in a concentration-dependent manner the ability of the endogenous p38αMAPK to phosphorylate an endogenous substrate MK2 in activated glia.
MW-150 dihydrochloride dihydrate blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC50 values are 332 nM and 936 nM for MK2 and IL-1β, respectively.
In Vivo: MW-150 dihydrochloride dihydrate (2.5 mg/kg; oral daily for 3−4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests.
MW-150 dihydrochloride dihydrate (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice.
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文献和实验实验试剂 Material Amount Storage Stability DAPI dihydrochloride (MW = 350
疟原虫 Malaria Parasites(Plasmodium)
can be used:Quinine dihydrochloride 20 mg salt/kg base given I.V. in 5% w/v dextrose or normal saline as a once-only 4 hour infusion followed, 4 hours later, by quinine dihydrochloride 10 mg salt/kg base 4-hour infusions 8 hourly.Where a syringe pump
DAPI Counterstaining Protocols
实验试剂 Choose one of the following forms of DAPI: DAPI dihydrochloride (MW = 350.3) DAPI dihydrochloride, FluoroPure™ grade (=98% pure) DAPI dilactate (MW = 457.5) For fluorescence microscopy
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