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- 文献和实验
- 技术资料
- 保存条件:
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
223749-46-0
- 规格:
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格: | 10 mM * 1 mL | 产品价格: | ¥1375.0 |
|---|---|---|---|
| 规格: | 1 mg | 产品价格: | ¥550.0 |
| 规格: | 5 mg | 产品价格: | ¥1250.0 |
| 规格: | 10 mg | 产品价格: | ¥2000.0 |
| 规格: | 25 mg | 产品价格: | ¥4300.0 |
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HMR 1556
CAS No. : 223749-46-0
MCE 国际站:HMR 1556
产品活性:HMR 1556 是色氨醇衍生物,是一种有效的 IKs 阻滞剂,在犬和豚鼠的左心室肌细胞中的 IC50 值分别为 10.5 nM、34 nM。
研究领域:Membrane Transporter/Ion Channel
作用靶点:Potassium Channel
In Vitro: HMR 1556 inhibits Ito, ICa,L and IKr with IC50s of 33.9 μM, 27.5 μM, 12.6 μM in canine left ventricular myocytes, respectively.
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文献和实验Physical Monitoring of HO-Induced Homologous Recombination
or HMR a , located near the ends of the same chromosome. These donor loci are maintained in a silent chromatin structure that prevents both their transcription and cleavage by HO, though they can still serve as donors in recombination. Most of the time
如果你做过序列差异分析,就会发现常用的方法包括单链构象多态性、变性梯度凝胶电泳、变性高效液相色谱、测序等,这些方法都需要分离样品。之后进行多步反应,操作繁琐,耗时长,且 PCR 产物有污染的风险。而 HMR 在 5 分钟之内就能完成,无需额外的步骤,也容易开发成高通量筛选,且是唯一的闭管操作,增加了分析的可靠性,这些优势对于分子诊断分析而言,格外重要。 如果你做 DNA 甲基化,HRM 分析还为你另辟蹊径。DNA 样品通过亚硫酸氢盐的处理,将未甲基化的胞嘧啶转化
和HMRα基因。这两个基因贮存了两种接合型等位基因,当转座给MAT基因座时就发生了接合型的转换。因此,MAT基因座是通过转座而转换其接合型的。MAT基因座的序列转换成另一个基因的序列,这种机制称为基因转换(gene convertion)。
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