Asukamycin,61116-33-4

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Asukamycin

CAS No. : 61116-33-4

MCE 国际站：Asukamycin

产品活性：Asukamycin 是一种 manumycin 型代谢产物，可以从 Streptomyces nodosus subsp. asukaensis 中分离出来。Asukamycin 是一种抗生素 (antibiotic)，具有抗菌活性。Asukamycin 抑制多种肿瘤细胞系的生长。

研究领域：Anti-infection  |  PROTAC

作用靶点：Antibiotic  |  Bacterial  |  Fungal  |  Molecular Glues

In Vitro: Asukamycin (1-50 μM; 24 h) in a concentration-dependent manner reduces viability of five different human cell lines with IC₅₀ of 1-5 μM.
Asukamycin (50 μM; 24 and 72 h; THP-1 cells) causes a significant increase in intracellular caspase 8 and caspase 3 activity.
Asukamycin (0-100 mcg/mL; bacteria, 18 h; fungus, 72 h) has antimicrobial activity. Asukamycin inhibits the growth of Gram-positive bacteria within a concentration range of 0.78-12.5 mcg/mL and inhibits the growth of Trichophyton mentagrophytes at a concentration of 25 mcg/ mL.

In Vivo: Asukamycin (0-450 mg/kg; i.p.; mice) has low toxicity in vivo. Asukamycin has acute toxicity with an LD₅₀ value of 48.5 mg/kg by intraperitoneal injection.

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