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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Gumarontinib; SCC244
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1264.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥500.0 |
| 规格： | 5 mg | 产品价格： | ￥1250.0 |
| 规格： | 10 mg | 产品价格： | ￥2000.0 |
| 规格： | 25 mg | 产品价格： | ￥3475.0 |
| 规格： | 50 mg | 产品价格： | ￥4850.0 |
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Glumetinib
CAS No. : 1642581-63-2
MCE 国际站：Glumetinib
产品活性：Glumetinib (SCC244) 是一种高选择性、口服生物利用度、ATP 竞争性 c-Met 抑制剂，IC50 为0.42 nM。Glumetinib 对 c-Met 的选择性超过 312 种激酶，包括 c-Met 家族成员 RON 和高度同源的激酶 Axl、Mer、TyrO3。Glumetinib 具有抗肿瘤活性。
研究领域：Protein Tyrosine Kinase/RTK
作用靶点：c-Met/HGFR
In Vitro: Glumetinib (SCC244) (0-10 nM; 72 hours) elicits selective and profound effects against c-Met–driven cancer cell proliferation.
Glumetinib (0-50 nM; 24 hours) induces G1–S phase cell-cycle arrest in c-Met–addicted human cancer cells.
In Vivo: Glumetinib (2.5-10 mg/kg; p.o.; once daily for 2-3 weeks) significantly inhibits c-Met–driven tumor growth in cancer CDX models.
Glumetinib shows significant antitumor efficiency in NSCLC and HCC tumor PDX models with MET aberration.
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