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| 规格： | 10 mM * 1 mL | 产品价格： | ￥1089.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥990.0 |
| 规格： | 10 mg | 产品价格： | ￥1400.0 |
| 规格： | 25 mg | 产品价格： | ￥3100.0 |
| 规格： | 50 mg | 产品价格： | ￥5500.0 |
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Protein kinase inhibitor 1 hydrochloride
CAS No. : 2321337-71-5
MCE 国际站：Protein kinase inhibitor 1 hydrochloride
产品活性：Protein kinase inhibitor 1 hydrochloride 是一种有效的 HIPK2 抑制剂，对 HIPK1 和 HIPK2 的 IC50 值分别为 136 和 74 nM，对 HIPK2 的 Kd 值为 9.5 nM。
研究领域：Protein Tyrosine Kinase/RTK
作用靶点：DYRK
In Vitro: Protein kinase inhibitor 1 hydrochloride is a potent HIPK2 inhibitor, with IC50s of 136 and 74 nM for HIPK1 and HIPK2, and a Kd of 9.5 nM for HIPK2. Protein kinase inhibitor 1 (Compound A64) is not an effective Cdk1 inhibitor (IC50 > 10 μM). A64 is moderately selective across a panel of kinases, with Kds of 3.7 nM (PIM3), 6.1 nM (CSNK2A2), 6.1 nM (CSNK2A2), 8.8 nM (DYRK1A), 9.5 nM (DAPK1), 31 nM (CSNK2A1), 37 nM (PIM1), 130 nM (DRAK2), 150 nM (CLK2), 190 nM (DRAK1), 220 nM (ULK2), 240 nM (CLK1), 250 nM (DYRK2), and 390 nM (ERK8) and IC50s of 19 nM (DYRK1A), 62 nM (DYRK1B), and 74 nM (HIPK2).
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文献和实验Kinase Inhibitor Profiling Using Chemoproteomics
Quantitative chemoproteomics has recently emerged as an experimental approach to determine protein interaction profiles of small molecules in a given cell line or tissue. In contrast to standard biochemical and biophysical kinase assays
Kinase Inhibitor Selectivity Profiling Using Differential Scanning Fluorimetry
and widely used approach is the direct measurement of the effect of the added ligands on its activity. A variety of enzymatic assay formats have been successfully applied for inhibitor screening of protein kinases. However, enzymatic assays require an active
Assaying Protein Kinase Activity
Protein kinases, encoded by approx 2% of eukaryotic genes, represent one of the major classes of cell-regulatory molecules. Assessment of the catalytic activity of a specific protein kinase can be an important step in elucidating signal
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