重组小鼠GM-CSF北京厂家

特别提示：包括重组小鼠GM-CSF在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组小鼠GM-CSF
英文名称：Recombinant Murine Granulocyte-Macrophage Colony Stimulating Factor
产品货号：GS4434
产品规格：5μg

分子量：Recombinant murine GM-CSF is a 14.1kDaglobular protein consisting of 124 amino acids residues.
储存条件：冷冻（-20℃）

概述

Granulocyte-Macrophage Colony Stimulating Factor(GM-CSF)is secreted by a number of different cell types(including activated T cells,B cells,macrophages,mast cells,endothelial cells and fibroblasts)in response to cytokine or immune and inflammatory stimulation.It was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors and has functions of stimulates the growth and differentiation of hematopoietic precursor cells from various lineages.GM-CSF has also been reported to have a functional role on non-hematopoietic cells and can induce human endothelial cells to migrate and proliferate.Additionally,it can stimulate the proliferation of a number of tumor cell lines,including osteogenic sarcoma,carcinoma and adenocarcinoma cell lines.Mouse GM-CSF shares 54%sequences identity with human GM-CSF,but has no biological effects across species.GM-CSF is used as a medication to stimulate the production of white blood cells following chemotherapy and has also recently been evaluated in clinical trials for its potential as a vaccine adjuvant in HIV-infected patients.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞98%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine FDC-P1 cells is less than 0.05ng/ml,corresponding to a specific activity of>2.0×107 IU/mg.
成分	Lyophilized from a 0.2μmfiltered solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rMuGM-CSF as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	APTRSPITVT RPWKHVEAIK EALNLLDDMP VTLNEEVEVV SNEFSFKKLT CVQTRLKIFE QGLRGNFTKL KGALNMTASY YQTYCPPTPE TDCETQVTTY ADFIDSLKTF LTDIPFECKK PGQK

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