重组人TWEAK Receptor北京供应商

特别提示：包括重组人TWEAK Receptor在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人TWEAK Receptor
英文名称：Recombinant Human TNF-related Weak Inducer of Apoptosis Receptor
产品货号：GS4540
产品规格：5μg

分子量：Approximately 5.6kDa,a single non-glycosylated polypeptide chain containing 53 amino acids.
储存条件：冷冻（-20℃）

概述

Human TNF-related weak inducer of apoptosis receptor(TWEAKR)also known as Tumor necrosis factor receptor superfamily member 12A precursor(gene name TNFRSF12A)or fibroblast growth factor-inducable 14 kDa protein,is distantly related to the TNFR family,containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain(DD)cytoplasmic region.It is expressed in the spleen,thymus,peripheral blood lymphocytes,colon,and small intestine.Signal transduction by TWEAK receptor can be activated by either the membrane anchored or the soluble TWEAK.In addition,It plays a role in TWEAK-induced endothelial cell migration,proliferation,and angiogenesis.Human and mouse TWEAK R share 82%a.a.sequence identity.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by inhibiting TWEAK-dependent proliferation of human umbilical vein endothelial cells(HUVEC)is less than 30ng/ml,corresponding to a specific activity of>3.3×104 IU/mg,in the presence of 15 ng/ml of rHuTWEAK.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rHuTWEAK Receptor as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP

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