重组人GDNF北京厂家

特别提示：包括重组人GDNF在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人GDNF
英文名称：Recombinant Human Glial Cell-derived Neurotrophic Factor
产品货号：GS4553
产品规格：2μg

分子量：Approximately 30.4kDa,a homodimeric protein consisting of two 135 amino acid non-glycosylated polypeptide chains.
储存条件：冷冻（-20℃）

概述

Glial cell-derived neurotrophic factor is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.It is a founding member of the GDNF family of ligands(GFL)and has been shown to interact with GFRA2 and GDNF family receptor alpha.GDNF(monomer)contains seven conserved cysteine residues,one of which(Cys 101)is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.Rat and human mature GDNF shows 93%sequence identity and have species cross-reactivity.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞97%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 0.1ng/ml,corresponding to a specific activity of>1.0×107 IU/mg.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in 20mMPB,500 mM NaCl,pH 6.4.
内毒素	Less than 1 EU/μg of rHuGDNF as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI

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