重组人M-CSF北京现货

特别提示：包括重组人M-CSF在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人M-CSF
英文名称：Recombinant Human Macrophage Colony Stimulating Factor
产品货号：GS4489
产品规格：2μg

分子量：Approximately 36.8kDa,a disulfide-linked homodimer consisting of two 158 amino acid polypeptide chains.
储存条件：冷冻（-20℃）

概述

Macrophage Colony Stimulating Factor(M-CSF),also named CSF-1,is a hematopoietic growth factor that is involved in the proliferation,differentiation,and survival of monocytes,macrophages,and bone marrow progenitor cells.It is produced by osteoblasts(as a result of endocrine stimulation by parathyroid hormone)exerts paracrine effects on osteoclasts and can interact with CSF1R.M-CSF is a four α-helical bundle cytokine and its active form is found extracellularly as a disulfide-linked homodimer.Four transcript variants encoding three different isoforms have been reported for M-CSF gene.Although forms may vary,all of them contain the N-terminal 150 a.a.portion that is necessary and sufficient for interaction with the receptor.The first 223 a.a.of mature human M-CSF shares 88%,86%,81%and 74%sequence identity with corresponding regions of dog,cow,mouse and rat M-CSF,respectively.Human M-CSF is active in the mouse,but mouse M-CSF is reported to be species-specific.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine M-NFS-60 cells is less than 1ng/ml,corresponding to a specific activity of>1.0×106 IU/mg.
成分	Lyophilized from a 0.2μmfiltered solution in PBS,pH7.4.
内毒素	Less than 1 EU/μg of rHuM-CSF as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water to a concentration of 0.1mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	EEVSEYCSHM IGSGHLQSLQ RLIDSQMETS CQITFEFVDQ EQLKDPVCYL KKAFLLVQDI MEDTMRFRDN TPNAIAIVQL QELSLRLKSC FTKDYEEHDK ACVRTFYETP LQLLEKVKNV FNETKNLLDK DWNIFSKNCN NSFAECSSQG HERQSEGS

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