重组人OPG北京厂家

特别提示：包括重组人OPG在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人OPG
英文名称：Recombinant Human Osteoprotegerin
产品货号：GS4402
产品规格：10μg

分子量：Approximately 19.7kDa,a single non-glycosylated polypeptide chain containing 173 amino acids.
储存条件：冷冻（-20℃）

概述

Osteoprotegerin(OPG),also named osteoclastogenesis inhibitory factor(OCIF),and tumor necrosis factor receptor superfamily member 11B(TNFRSF11B),is a TNFRSF11B-encoded protein in humans.OPG is a 401 a.a.basic glycoprotein which comprises 7 structural domains.It is either a 60 kDa monomer or a 120 kDa dimer linked by disulfide bridges.OPG acts as a decoy receptor for the receptor activator of nuclear factor kappa B ligand(RANKL)and inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro and may also play a role in preventing arterial calcification.OPG has been applied to decrease bone resorption in women with postmenopausal osteoporosis and in patients with lytic bone metastases.Mature human OPG shares 86%,87%,92%,92%and 88%amino acid sequence identity with mouse,rat,equine,canine and bovine OPG,respectively.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10ng/ml,corresponding to a specific activity of>1.0×105 IU/mg in the presence of 10ng/mL soluble rHuRANKL(sRANKL).
成分	Lyophilized from a 0.2μmfiltered concentrated solution in 20mMPB,150 mM NaCl,pH 6.0.
内毒素	Less than 1 EU/ug of rHuOPG as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/ml.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	ETFPPKYLHY DEETSHQLLC DKCPPGTYLK QHCTAKWKTV CAPCPDHYYT DSWHTSDECL YCSPVCKELQ YVKQECNRTH NRVCECKEGR YLEIEFCLKH RSCPPGFGVV QAGTPERNTV CKRCPDGFFS NETSSKAPCR KHTNCSVFGL LLTQKGNATH DNICSGNSES TQK

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