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- 2026年06月28日
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文献和实验Clostridium difficile Toxinotyping
Clostridium difficile shows considerable variability in the PaLoc region encoding two main virulence factors, toxins TcdA and TcdB. Strains with changes in PaLoc are defined as variant toxinotypes and currently 27 such groups are recognized
Clostridium difficile and the Disease It Causes
Clostridium difficile is a spore-forming, toxin-producing, anaerobic bacterium abundant in soils and water. Frequent and early colonization of the human intestinal flora is common and often asymptomatic. Antimicrobials given commonly disrupt
Synthesis of a 4‐Selenothymidine Phosphoramidite and Incorporation into Oligonucleotides
oligonucleotides retain base?pairing like their native counterparts, and the derivatized DNA structure is virtually identical to the native structure. This achievement will present a novel opportunity for structural studies of nucleic acids and their protein
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