- ￥1580 - 4020
- Elabscience
- E-AB-60646
- 武汉
- 2026年09月23日
- WB;IHC
- Rabbit
- Human;Mouse;Rat
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- 文献和实验
- 技术资料
- 抗体名：
(KO Validated) Caspase-3 Polyclonal Antibody_货号:E-AB-60646_多克隆抗体
- 抗体英文名：
(KO Validated) Caspase-3 Polyclonal Antibody
- 靶点：
Caspase-3
- 浓度：
5 μL/Test
- 应用范围：
WB;IHC
- 宿主：
Rabbit
- 适应物种：
Human;Mouse;Rat
- 保质期：
12个月
- 级别：
科研
- 库存：
99
- 供应商：
武汉伊莱瑞特生物科技股份有限公司
- 标记物：
Unconjugated
- 克隆性：
Polyclonal
- 保存条件：
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
- 形态：
液体
- 亚型：
IgG
- 规格：
200μL/120μL/60μL
| 规格： | 200μL | 产品价格： | ￥4020.0 |
|---|---|---|---|
| 规格： | 120μL | 产品价格： | ￥2520.0 |
| 规格： | 60μL | 产品价格： | ￥1580.0 |
货号：E-AB-60646
| Verified Samples |
Verified Samples in WB:Jurkat,293T
Verified Samples in IHC:Rat spleen,Human tonsil |
| Dilution |
WB 1:500-1:2000, IHC 1:50-1:200
|
| Clonality |
Polyclonal
|
| Isotype |
IgG
|
| Immunogen |
Recombinant fusion protein of human Caspase-3 (NP_004337.2).
|
| Abbre |
Caspase-3
|
| Synonyms |
CPP32;CPP32B;SCA-1;Active Caspase 3;CASP3;active Caspase-3;Caspase 3;Caspase-3 p12;caspase-3抗体
|
| Swissprot |
P42574
|
| Calculated MW |
31kDa
|
| Observed MW |
17kDa/35kDa
|
| Cellular Localization |
Cytoplasm.
|
| Concentration |
1mg/mL
|
| Storage |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
|
| Buffer |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
|
| Purification Method |
Affinity purification
|
| Research Areas |
Cancer; Cell Biology; Metabolism; Neuroscience
|
| Conjugation |
Unconjugated
|
| Background |
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
|
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文献和实验Construction of Polyclonal Antibody Libraries Using Phage Display
Polyclonal antibody libraries (PCALs) are standardized mixtures of antibodies (Abs) specific for an antigen (Ag) or multi-Ag target (a poly-Ag). As the immunoglobulin (Ig) genes are cloned, the mixtures can be perpetuated, amplified
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呈递水平，E-F 为肿瘤生长曲线与抑制率，I-M 为 T 细胞浸润分析 三、Absin 产品助力：关键试剂赋能研究全程 本研究的顺利开展，离不开 Absin 优质产品的稳定支持，其中兔抗 CD274 多克隆抗体（货号：abs115675）和抗荧光淬灭剂（货号：abs9235）发挥了重要作用： 1. 核心产品及应用场景 Absin 产品 货号 研究应用 对应原文图表 兔抗 CD274 多克隆抗体 abs115675 检测肿瘤细胞表面 PD-L1 蛋白表达水平，验证 CPSA 对 PD-L1 的上调
and how they were validated for use in the system under study （i.e. assay and species）。类似对抗体验证（抗体特异性）的质疑不再仅限于 science，nature 等高分杂志，由于生物试剂普遍存在的特异性问题导致实验结果不可重复1，已经引起主流学术期刊的关注。编辑们正逐渐提高对抗体特异性问题的重视，并要求提供抗体特异性的证据。事实上，抗体的特异性问题，就是我们常说的「脱靶」。市面上抗体的品质良莠不齐，有相当一部分抗体并不能正确识别您想研究的靶标。想想是不是
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