Citric acid柠檬酸,77-92-9

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Citric acid

CAS No. : 77-92-9

MCE 国际站：Citric acid

产品活性：Citric acid 是柑橘类水果中发现的弱有机三羧酸。柠檬酸是天然防腐剂和食品添加剂。

研究领域：Apoptosis  |  Anti-infection  |  Metabolic Enzyme/Protease

作用靶点：Apoptosis  |  Bacterial  |  Endogenous Metabolite  |  Antibiotic

结构分类：酮、醛、酸

In Vitro: Citric acid induces apoptosis through the mitochondrial pathway in the human keratinocyte cell line HaCaT. It inhibits proliferation of HaCaT cells in a dose-dependent manner, but also induces apoptosis and cell cycle-arrest at the G2/M phase (before 24 h) and S phase (after 24 h).

In Vivo: Citric acid is found in all animal tissues as an intermediary substance in oxidative metabolism. The administration of citric acid (1–2 g/kg) attenuates LPS-induced elevations in brain MDA, nitrite, TNF-α, GPx, and PON1 activity. In the liver, nitrite is decreased by 1 g/kg citric acid. Citric acid (1-2 g/kg) decreases brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation. Citric acid supplementation increases intestinal calcium and phosphorus absorption and the retention/intake ratio only in rats fed the 1% Ca diet. Citric acidsupplementation together with a calcium-rich diet allows to obtain an increased retention of calcium and phosphorus in bone. The prolonged administration of calcium citrate supplements may therefore help to increase bone mineral concentration. Oral administration of citric acid ameliorates ketosis and protects against the development of diabetic complications in an animal model of type 1 diabetes.

相关产品：Natural Product Library Plus  |  Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Apoptosis Compound Library  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  Natural Product Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  Human Endogenous Metabolite Compound Library  |  Drug Repurposing Compound Library  |  Anti-diabetic Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Antibacterial Compound Library  |  Ferroptosis Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  Medicine Food Homology Compound Library  |  Orally Active Compound Library  |  Traditional Chinese Medicine Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Antibiotics Library  |  Food Additive Library   |  Food-Sourced Compound Library   |  Inactive Ingredient Library  |  Rare Diseases Drug Library  |  Anti-Cancer Natural Product Library  |  MG-132  |  Rapamycin  |  3-Methyladenine  |  LY294002  |  Doxorubicin hydrochloride  |  Chloroquine  |  Bafilomycin A1  |  Y-27632 dihydrochloride  |  Paclitaxel  |  Puromycin dihydrochloride  |  Acetylcysteine  |  Dexamethasone  |  Angiotensin II human  |  Tamoxifen  |  Cycloheximide  |  Staurosporine  |  2-Deoxy-D-glucose  |  Bortezomib  |  5-Fluorouracil  |  Sorafenib  |  SP600125  |  Trametinib  |  G-418 disulfate  |  Temozolomide  |  ATP  |  Gemcitabine  |  MK-2206 dihydrochloride  |  Retinoic acid  |  Verteporfin

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物  |  寡核苷酸

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。