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- 技术资料
- 保存条件：
4°C, stored under nitrogen
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
533-31-3
- 规格：
10 mM * 1 mL/5 g/10 g/25 g/50 g/100 g/250 g/500 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥110.0 |
|---|---|---|---|
| 规格： | 5 g | 产品价格： | ￥100.0 |
| 规格： | 10 g | 产品价格： | ￥145.0 |
| 规格： | 25 g | 产品价格： | ￥257.0 |
| 规格： | 50 g | 产品价格： | ￥360.0 |
| 规格： | 100 g | 产品价格： | ￥505.0 |
| 规格： | 250 g | 产品价格： | ￥860.0 |
| 规格： | 500 g | 产品价格： | ￥1205.0 |
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Sesamol
CAS No. : 533-31-3
MCE 国际站：Sesamol
产品活性：Sesamol 是芝麻油的主要成分，Sesamol 是一种自由基清除剂，在 DPPH 实验中，IC50 为 5.95±0.56 μg/mL。具有抗氧化活性。抗肿瘤活性。
研究领域：Apoptosis
作用靶点：Apoptosis
In Vitro: Sesamol has also been shown to be a classical inhibitor of lipid peroxidation.
Sesamol (0-1 mM) efficiently induces the apoptosis of human liver hepatocellular carcinoma (HepG2) cells.
Sesamol suppresses cell proliferation and induces intrinsic and extrinsic apoptosis in HepG2 cells.
Sesamol treatment elicites mitochondrial dysfunction by inducing a loss of mitochondrial membrane potential. Sesamol inhibits mitophagy and autophagy through impeding the PI3K Class III/Belin-1 pathway. Sesamol decreases the expression of anti-apoptotic protein Bcl-2, but shows no effect on the expression of apoptotic signal Bax. Sesamol improves the protein expression of Fas/FasL, and activates tBid and caspase-8 which are all involved in the extrinsic apoptosis pathway.
In Vivo: Sesamol treatment for 35 days does not significantly impact body weight, although the tumor volume is dramatically inhibited (40.56% size inhibitory rate with Sesamol at 200 mg/kg compared to the control group). However, a lower dose (100 mg/kg Sesamol) only has significant anti-tumor growth effect up to 27 days after the first treatment.
The Bcl-2/Bax ratio in tumor tissues is also decreased. Moreover, in the Sesamol treatment group, levels of the cell proliferation marker Ki76 are down-regulated, and levels of the cell apoptosis marker cleaved-caspase 3 are increased when compared to control. The expression of LC3 protein is remarkably decreased by Sesamol in a dose-dependent manner.
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文献和实验、棕榈酸等甘油脂以及芝麻素（ d-sesamin）、芝麻酚（ sesamol）、芝麻酚素（ sesamolin）、二十四酸、甾醇、维生素 E等，供食用或工业用。黑芝麻用于医药可补血、润肠、通乳，主治贫血、便秘、乳水不足。 H．梅尔希奥将本科列入管花目的茄亚目（等同于玄参目）， A．Л．塔赫塔江及 A．克朗奎斯特均将其列入玄参目。一般认为此科和紫葳科、角胡麻科（ Martyniaceae）相近。
0.0005 1 1.000 3.078 6.314 12.706 31.821 63.657 127.321 318.309 636.619 2 0.816 1.886 2.920 4.303 6.965 9.925 14.089 22.327 31.599 3 0.765 1.638 2.353 3.182 4.541 5.841 7.453 10.215 12.924 4 0.741 1.533 2.132 2.776 3.747 4.604
：未见Hp一；偶见1~2只形态不能肯定为Hp者，+；少量高倍镜视野中偶见Hp；++等介于+和+++之间，++++见到大量或Hp成团者。 2 结果 本组712例胃镜病理结果显示：Hp阳性379例，感染率为53.2%。其中：男254例占67%，女215例，占33%（表2）。汉族333例，占87.9%，少数民族46例，占12.1%（表3）。老年人45例，占11.9%，非老年334例，占88.1%（表1）， 慢性胃炎 533例。 表
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