Tyrosol酪醇,501-94-0

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Tyrosol

CAS No. : 501-94-0

MCE 国际站：Tyrosol

产品活性：Tyrosol 是苯乙醇的衍生物。Tyrosol 减弱来自星形胶质细胞的促炎细胞因子，且降低 NF-κB 活化。具有抗氧化和抗炎作用。

研究领域：NF-κB  |  Metabolic Enzyme/Protease

作用靶点：NF-κB  |  Endogenous Metabolite

结构分类：酚类  |  单酚类

来源：植物  |  橄榄科  |  橄榄

In Vitro: Tyrosol (1.6 mM) significantly increases the cell viability of cultured astrocytes exposed to oxygen glucose deprivation (OGD).
Tyrosol (1.6 mM) attenuates the released TNF-α and IL-6 level from astrocyte via regulating Janus N-terminal kinase (JNK) .
The reduction of cytokines from astrocyte might be due to its inhibition of astrocyte activation and regulation of STAT3 signaling pathway since Tyrosol (1.6 mM) attenuates the expression level of GFAP (glial fibrillary acidic protein) and the phosphorylation of STAT3.
Tyrosol prevents the degradation of IκBα and the increase of IκBα phosphorylation in astrocytes exposed to OGD, which leads to the suppression of NF-κB function during ischemia.

In Vivo: Sub-plantar injection of carrageenan causes a noticeable increase in paw thickness, reaching a peak after 2 h post-injection. This effect is reduced when Tyrosol (0.5 mg/kg) or Tyrosol-sulphate is injected prior to the treatment with carrageenan. Similar AUC values for paw oedema are obtained after the administration of Tyrosol at a dose of 0.5 mg/kg and Tyrosol-sulphate at a dose of 0.1 mg/kg.

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