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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
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MedChemExpress LLC
- CAS号：
104594-70-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg/200 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥500.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥225.0 |
| 规格： | 5 mg | 产品价格： | ￥450.0 |
| 规格： | 10 mg | 产品价格： | ￥540.0 |
| 规格： | 25 mg | 产品价格： | ￥750.0 |
| 规格： | 50 mg | 产品价格： | ￥900.0 |
| 规格： | 100 mg | 产品价格： | ￥1080.0 |
| 规格： | 200 mg | 产品价格： | ￥1300.0 |
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Caffeic acid phenethyl ester
CAS No. : 104594-70-9
MCE 国际站：Caffeic acid phenethyl ester
产品活性：Caffeic acid phenethyl ester 是一种 NF-κB 抑制剂。
研究领域：NF-κB | Apoptosis
作用靶点：NF-κB | Apoptosis
In Vitro: Caffeic acid phenethyl ester is a NF-κB inhibitor. Cell survival and proliferation of CRPC cell lines are all significantly suppressed by Caffeic acid phenethyl ester (CAPE) treatment dose-dependently. The growth inhibitory effect of Caffeic acid phenethyl ester is evident within 24 hours of treatment but the suppressive effect accumulates over time. The IC50 of 24, 48, 72, and 96 h Caffeic acid phenethyl ester treatment on LNCaP 104-R1 cells is 64.0, 30.5, 20.5, and 18.0 μM, respectively. Colony formation assay reveals that treatment with 10 μM Caffeic acid phenethyl ester reduces colony formation of LNCaP 104-R1 cells by 90% while treatment with 20 μM Caffeic acid phenethyl ester completely blocks the formation of LNCaP 104-R1 colonies. Flow cytometric analysis reveals a reduction of cells in the S phase and G2/M phase but an increase of cells in the G1 phase population in LNCaP 104-R1 cells under Caffeic acid phenethyl ester treatment. Caffeic acid phenethyl ester treatment also significantly decreases protein levels of fatty acid synthase (FAS), retinoblastoma protein (Rb), phospho-Rb Ser807/811, c-Myc, p70S6kinase, phospho-p70S6kinase Thr421/Ser424, Skp2, p90RSK, and NF-κB p65.
In Vivo: Administration of Caffeic acid phenethyl ester (CAPE) by gavage (10 mg/kg body weight per day) for eight weeks results in 50% reduction of tumor volume, suggesting that Caffeic acid phenethyl ester treatment retards the growth of LNCaP 104-R1 xenografts. Caffeic acid phenethyl ester gavage slows down the tumor growth of LNCaP 104-R1 cells, which is consistent with our observation that Caffeic acid phenethyl ester treatment induces cell cycle arrest but not apoptosis.
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文献和实验亦称3， 4-二羟基桂皮酸。在咖啡豆中，虽与奎尼酸（ quinic acid）形成结合物（氯原酸）大量存在，但在一般高等植物中常以游离酸、甲酯、奎宁酸，少数情况下以葡萄糖结合物的形态广泛存在。易受酚氧化酶的氧化，是组织发生褐色变化的重要原因之一。对植物的生长有抑制作用，是生长抑制物质——抑制剂β的成分之一。可抑制过氧化物酶、吲哚乙酸氧化酶的作用。在生物体内，它是由 L-苯丙氨酸脱氨基后生成的反式桂皮酸逐次地羟化而合成的。
) cultures for the production of adventitious root biomass and caffeic acid derivatives. This chapter describes the methodologies of induction of adventitious roots from explants of E. purpurea , propagation of adventitious roots
are observed for epicatechin gallate, epigallocatechin gallate, quercetin, fisetin, epigallocatechin, catechin, and caffeic acid in this order, in accord with the number and position of the –OH groups as well the conjugation level of the molecule
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