Astaxanthin虾青素,472-61-7

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Astaxanthin

CAS No. : 472-61-7

MCE 国际站：Astaxanthin

产品活性：Astaxanthin，红色膳食类胡萝卜素，是一种口服有效的强效抗氧化剂。Astaxanthin 可抑制 NF-κB，能在蛋白质水平下调高血糖中的 VEGF。Astaxanthin 通过激活 PPARγ 并减少 STAT3 和相关通路蛋白的表达，发挥抗癌细胞增殖、增加凋亡以及削弱迁移和侵袭的活性。Astaxanthin 还具有神经保护和抗炎活性可用于癌症，糖尿病视网膜病变，心血管疾病等研究以及动物饲料的着色。

研究领域：Cell Cycle/DNA Damage  |  Vitamin D Related/Nuclear Receptor  |  Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  JAK/STAT Signaling  |  Stem Cell/Wnt  |  Apoptosis

作用靶点：PPAR  |  Reactive Oxygen Species  |  STAT  |  NF-κB  |  Apoptosis

In Vitro: Astaxanthin (50, 100, 150, 200 µM; 48 h) inhibits the proliferation of DU145 cells (IC₅₀<200 µM).
Astaxanthin (200 µM; 24 h) reduces the expression of STAT3 and the related pathway proteins (at both protein and mRNA levels) by inhibiting proliferation, increasing apoptosis and weakening migration and invasion
Astaxanthin protects RPE cells from abnormal activation and oxidative stress (induced by high glucose) by down-regulating VEGF in high glucose at protein levels.
Astaxanthin (1-50 µM; 72 h) upregulates protein expression of PPARγ in time- and dose-dependent manners in K562 cells.

In Vivo: Astaxanthin (200 mg/kg; intragastric administration; once daily for 3 weeks) inhibits the growth of DU145 tumor xenografts in nude mice.
Astaxanthin (125 or 500 mg/kg; in animal feedings; 7 days) provides significant cardioprotection and reduces oxidative stress in rats.

相关产品：Natural Product Library Plus  |  Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  Bioactive Compound Library Plus  |  MG-132  |  Phorbol 12-myristate 13-acetate  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  LY294002  |  Tamoxifen  |  Paclitaxel  |  Y-27632  |  Acetylcysteine  |  Angiotensin II human  |  2-Deoxy-D-glucose  |  Staurosporine  |  H2DCFDA  |  SB-431542  |  Actinomycin D  |  Deferoxamine mesylate  |  Bortezomib  |  5-Fluorouracil  |  Trametinib  |  Sorafenib  |  Oxaliplatin  |  Gemcitabine  |  Temozolomide  |  Rotenone  |  Mdivi-1  |  Retinoic acid  |  Elesclomol  |  Ruxolitinib  |  Decitabine  |  SP600125

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds