NucPE1,1404091-23-1

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

NucPE1

CAS No. : 1404091-23-1

MCE 国际站：NucPE1

产品活性：NucPE1 (Nuclear Peroxy Emerald 1) 是核定位荧光过氧化氢探针, 其特异性定位于细胞核，没有附加的靶向部分。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Reactive Oxygen Species

In Vitro: NucPE1 features two major visible region absorptions (λ_abs=468 nm, ε=27,300 M^-1cm^-1; λ_abs=490 nm, ε=26,000 M^-1cm^-1) and a weak emission (λ_em=530 nm, Φ=0.117). Reaction of NucPE1 with H₂O₂ triggers a fluorescence increase upon its conversion to fluorophore NucPE1, which possesses one major absorption band at 505 nm (ε=19,100 M^-1cm^-1) with enhanced emission (λ_em=530 nm, Φ=0.626). NucPE1 selectively accumulates in the nuclei of a variety of mammalian cell lines as well as in whole model organisms like C. clegans, where it can respond to subcellular changes in H₂O₂ fluxes.

In Vivo: NucPE1 maintains the ability to selectively target nuclei in vivo. NucPE1 imaging reveals a reduction in nuclear H₂O₂ levels in worms overexpressing sir-2.1 compared to wildtype congeners, supporting a link between this longevity-promoting sirtuin protein and enhanced regulation of nuclear ROS pools.

相关产品：Acetylcysteine  |  H2DCFDA  |  Deferoxamine mesylate  |  Elesclomol  |  Quercetin  |  MitoSOX Red  |  L-Ascorbic acid  |  Mito-TEMPO  |  Mitoquinone mesylate  |  L-Glutathione reduced  |  Trolox  |  Zinc Protoporphyrin  |  FX-11  |  Dimethyl fumarate  |  Diphenyleneiodonium chloride  |  Berberine chloride  |  Urolithin A  |  TPEN  |  Sodium dichloroacetate  |  Tempol  |  2-Methoxyestradiol  |  GSK2795039  |  α-Vitamin E  |  Ciprofloxacin  |  Trabectedin  |  Coenzyme Q10  |  Piperlongumine  |  Chlorogenic acid  |  Ellagic acid  |  L-Ascorbic acid 2-phosphate trisodium

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds