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- 文献和实验
- 技术资料
- 保存条件:
polypeptide, sealed storage, away from moisture
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- 规格:
5 mg/10 mg
| 规格: | 5 mg | 产品价格: | ¥1800.0 |
|---|---|---|---|
| 规格: | 10 mg | 产品价格: | ¥2700.0 |
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SV40 large T antigen NLS
MCE 国际站:SV40 large T antigen NLS
产品活性:SV40 large T antigen NLS 是一种多肽,来源于 SV40 大 T 抗原 47-55 的氨基酸序列,能够将蛋白运输到细胞核。
研究领域:Others
作用靶点:Others
In Vitro: SV40 large tumor-antigen (T-ag) nuclear import is enhanced by the protein kinase CK2 (CK2) site (Ser111Ser112) flanking the nuclear localization sequence (NLS). T-ag NLS can enhance nuclear import, despite the fact that PK-C has been shown to inhibit nuclear import of proteins such as lamin B2.
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文献和实验Methods to Assess Inhibition of Adipocyte Differentiation by SV40 Large T Antigen
. Preadipocytes transformed by a variety of oncogenic proteins, such as the Simian virus 40 (SV40) large-tumor antigen (SVLT) or activated ras oncogene (1 –6 ) and others, fail to differentiate into adipocytes. However, the transformation and differentiation
SV40 large T antigen (T-ag) is an oncoprotein that induces transformation of cells through the binding and inactivation of the p53 tumor suppressor protein and the retinoblastoma family of proteins. This chapter focuses on the interaction
Biology of p53 and SV40 Large T Association
p53 was discovered because of its capacity to bind to SV40 large T antigen (SVLT) in transformed cell lines (1 ,2 ). It is a phosphorylated, 393 amino acid protein, with five blocks of sequences that are highly conserved
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