MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 131334-43-5
MCE 国际站:PLP 139-151
产品活性:PLP (139-151) 是髓鞘蛋白脂蛋白 (PLP) 139至151氨基酸片段。用于诱导实验性自身免疫性脑脊髓炎 (EAE)。
研究领域:Others
作用靶点:Others
In Vitro: Severe clinical and histological EAE could be induced by adoptive transfer of the peptide-specific T cell line and 3 of 4 T cell clones. The T cell line/clones all responded strongly to PLP (139-151) in in vitro proliferative assays. Line SPL and all of the clones show strong proliferative response to the whole PLP molecule and to PLP (139-151).
In Vivo: PLP (139-151) induces acute experimental allergic encephalomyelitis (EAE) in SJL/J mice. Beginning on Day 9, the mice treated with PLP (139-151) show signs of EAE and the disease progressed rapidly to paralysis. Central nervous system inflammation, edema, gliosis, and demyelination are found in all mice killed between Days 10 and 28. Young male SJL mice immunized with a major encephalitogenic peptide of myelin, PLP 139-151, develop initial clinical and histological symptoms of EAE with a severity similar to age-matched females; however, unlike females, male mice does not relapse. Significant T cell proliferation to PLP 139-151, but not to other PLP and myelin basic protein (MBP) epitopes, is observed in both males and females during the initial episode, recovery, and first relapse of clinical disease.
相关产品:Bioactive Compound Library Plus | PEG300 | SBE-β-CD | Corn oil | Tween 80 | Polyethylene glycol 12-hydroxystearate | JC-1 | DTT | CFSE | Digitonin | Lipopolysaccharides | Thiazolyl Blue | D-Luciferin potassium salt | (2-Hydroxypropyl)-β-cyclodextrin | Methyl-β-cyclodextrin | Biotin | Monocrotaline | Auxinole | Nile Red | 3X FLAG peptide TFA | FLAG peptide | Tocofersolan | DAPI dihydrochloride | Propidium Iodide | Cremophor EL | Yoda 1 | IPTG | Calcein-AM | GsMTx4 TFA
品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪前沿的制药及生命科学研究进展,为您提供全球前沿的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。