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- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture and light
- 英文名：
Enoxacin sesquihydrate; AT-2266 hydrate; CI-919 hydrate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
84294-96-2
- 规格：
100 mg/500 mg
| 规格： | 100 mg | 产品价格： | ￥500.0 |
|---|---|---|---|
| 规格： | 500 mg | 产品价格： | ￥800.0 |
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Enoxacin hydrate
CAS No. : 84294-96-2
MCE 国际站：Enoxacin hydrate
产品活性：Enoxacin hydrate (Enoxacin sesquihydrate) 是一种氟喹诺酮，可以干扰 DNA 复制，抑制细菌 DNA 促旋酶 (IC50=126 µg/ml) 和拓扑异构酶 IV (IC50=26.5 µg/ml)。Enoxacin hydrate 是一种 miRNA 加工激活剂，可增强 siRNA 介导的 mRNA 降解并促进内源性 miRNA 的生物发生，也可增强 TAR RNA 结合蛋白 2 (TRBP) 介导的 microRNA 加工。Enoxacin hydrate 有效抑制革兰氏阳性和阴性细菌， 是一种特异性的癌症生长抑制剂。
研究领域：Anti-infection | Cell Cycle/DNA Damage | Epigenetics
作用靶点：Bacterial | DNA/RNA Synthesis | MicroRNA | Antibiotic
In Vitro: Enoxacin hydrate (Enoxacin sesquihydrate) increases siGFP-mediated gene knockdown mediated by siRNA against EGFP in HEK293 cells-based reporter system in a dose-dependent manner, with a median effective concentration (EC50) of ~30 µM, whereas it has no effect on the cells expressing GFP only. Enoxacin (50 µM) promotes the processing of miRNAs and the loading of siRNA duplexes onto RISCs in HEK293 cells.
Enoxacin has no effect on the processing of pre-let-7 or pre-miR-30a by Dicer alone. However, the addition of Enoxacin can enhance the processing of let-7 or pre-miR-30a by Dicer and TRBP together.
Enoxacin inhibits 90% Escherichia coli, Klebsiella sp., Aeromonas sp., Enterobacter spp., Serratia spp., Proteus mirabilis, and Morganella morganii at less than or equal to 0.8 micrograms/ml.
In Vivo: Enoxacin hydrate (Enoxacin sesquihydrate; 100 µM; 2 µl; injected into ear once a day for 3 consecutive days (days 12, 13 and 14)) enhances the the GFP mRNA knockdown efficiency by Lv-siGFP (from 80% to 60%; 40% GFP mRNA level remained), whereas alone has no effect on GFP expression in GFP transgenic line C57BL/6-Tg(ACTB-EGFP)1Osb/J (10 d old) with lentivirus expressing shGFP (Lv-siGFP; injected into ear for 10 days).
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文献和实验Partial proteolysis with Staph. aureus V8 protease
mm (which is the size of the 28-tooth comb wells). Rehydrate the gel pieces in 100 microliters of rehydration/overlay buffer for 1-2 min. Do not over-hydrate. The pieces will become too fragile and will fragment. Place the gel pieces
enzyme immobilization method that overcomes the foresaid limitations. It is based on the specific interaction between His-tagged enzyme and single-walled carbon nanotubes modified with N α ,N α -bis(carboxymethyl)-l -lysine hydrate. This method
for each d12 mm coverslip, 25 µl for square coverslip and 50µl for full size coverslip• Seal the coverslip with nail polish• Store in 4 C up to 2 weeksDAPI stock• 4’, 6-Diamidino-2-phenylindole dihydrochloride hydrate (DAPI) from Sigma (Cat# D-9542), 1 mg 1mg
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