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- 详细信息
- 技术资料
- 保存条件:
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名:
CP 62993
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
83905-01-5
- 规格:
10 mM * 1 mL/50 mg/100 mg/200 mg/500 mg
| 规格: | 10 mM * 1 mL | 产品价格: | ¥880.0 |
|---|---|---|---|
| 规格: | 50 mg | 产品价格: | ¥800.0 |
| 规格: | 100 mg | 产品价格: | ¥1250.0 |
| 规格: | 200 mg | 产品价格: | ¥2000.0 |
| 规格: | 500 mg | 产品价格: | ¥3800.0 |
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
Azithromycin
CAS No. : 83905-01-5
MCE 国际站:Azithromycin
产品活性:Azithromycin (CP-62993) 是一种大环内酯抗生素,常用于细菌感染的研究。
研究领域:Anti-infection | Autophagy
作用靶点:Bacterial | Autophagy | Antibiotic | Parasite
In Vitro: Azithromycin (2 μM) augments rhinovirus-induced IFNβ expression in primary bronchial epithelial cells from asthmatics, which is associated with over-expression of RIG-I like receptors and repression of viral replication. Knockdown of MDA5, but not knockdown of RIG-I, diminishes azithromycin (2 μM)-enhanced viral-induced IFNβ expression in asthmatic primary bronchial epithelial cells. Azithromycin specifically reduces MMP-9 mRNA and protein levels without affecting NF-κB in endotoxin-challenged monocytic THP-1 cells.
In Vivo: Azithromycin (50 mg/kg) has no effect on bronchoalveolar lavage inflammatory parameters and LDH levels in a mouse model of asthma exacerbation. Azithromycin induces neither general inflammatory parameters nor LDH release in a mouse model of asthma exacerbation, and augments expression of interferon-stimulated genes and the pattern recognition receptor MDA5 but not RIG-I in exacerbating mice.
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