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- 文献和实验
- 技术资料
- 保存条件：
-80°C, protect from light, stored under nitrogen
- 英文名：
TP-434 dihydrochloride; TP-434-046
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1334714-66-7
- 规格：
1 mg/5 mg
| 规格： | 1 mg | 产品价格： | ￥2400.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥8500.0 |
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Eravacycline dihydrochloride
CAS No. : 1334714-66-7
MCE 国际站：Eravacycline dihydrochloride
产品活性：Eravacycline dihydrochloride (TP-434 dihydrochloride) 是一种有效的广谱抗菌剂。
研究领域：Anti-infection
作用靶点：Bacterial
In Vitro: Eravacycline is potent antibiotic against A. baumannii, including isolates that are resistant to sulbactam, SM 7338,? and BAY 41-6551. Eravacycline shows greater activity than BAY 41-6551, and colistin. The Eravacycline dihydrochloride MIC50/90 values are 0.5/1 mg/L. Eravacycline shows inhibitory effects on six E. coli with MICs ranging from 0.125 to 0.25 mg/L. Eravacycline dihydrochloride is a synthetic antibiotic, with inhibits bacterial protein synthesis through binding to the 30S ribosomal subunit. Eravacycline displays broad spectrum activity against gram-negative bacteria in the panel except P. aeruginosa, as well as excellent activity against major gram-positive pathogens, including methicillin-resistant S. aureus. Eravacycline also displays potent ribosomal inhibition. Eravacycline shows potent broad-spectrum activity against 90% of the isolates (MIC90) in each panel at concentrations ranging from ≤0.008 to 2 μg/mL for all species panels except those of Pseudomonas aeruginosa and Burkholderia cenocepacia ((MIC90) values of 32 μg/mL for both organisms). Eravacycline is active against multidrug-resistant bacteria, including those expressing extended-spectrum β-lactamases and mechanisms conferring resistance to other classes of antibiotics, including carbapenem resistance.
In Vivo: Eravacycline dihydrochloride is active in multiple murine models of infection against clinically important Gram-positive and Gram-negative pathogens. Eravacycline is efficacious in mouse septicemia models, demonstrating 50% protective dose values of ≤1 mg/kg of body weight once a day (q.d.) against Staphylococcus aureus. The PD50 values against Escherichia coli isolates are 1.2 to 4.4 mg/kg q.d.
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can be used:Quinine dihydrochloride 20 mg salt/kg base given I.V. in 5% w/v dextrose or normal saline as a once-only 4 hour infusion followed, 4 hours later, by quinine dihydrochloride 10 mg salt/kg base 4-hour infusions 8 hourly.Where a syringe pump
Measuring Antioxidant Capacity Using the ORAC and TOSC Assays
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for each d12 mm coverslip, 25 µl for square coverslip and 50µl for full size coverslip• Seal the coverslip with nail polish• Store in 4 C up to 2 weeksDAPI stock• 4’, 6-Diamidino-2-phenylindole dihydrochloride hydrate (DAPI) from Sigma (Cat# D-9542), 1 mg 1mg
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