Ceftobiprole

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Ceftobiprole

CAS No. : 209467-52-7

MCE 国际站：Ceftobiprole

产品活性：Ceftobiprole (Ro 63-9141) 是一种广谱头孢菌素，对甲氧西林 (MRSA)、耐万古霉素葡萄球菌 (VRSA) 和耐青霉素链球菌具有高水平的体外活性，对 MRSA 的 MIC₉₀ 值为 2 μg/mL。Ceftobiprole 还抑制革兰氏阳性和革兰氏阴性病原体。

研究领域：Anti-infection

作用靶点：Bacterial  |  Antibiotic

In Vitro: Ceftobiprole (Ro 63-9141) has demonstrates activity against important gram-positive bacteria, including S. pneumonia (PRSP), Methicillin-resistant S. aureus (MRSA), and E. faecalis with MIC₉₀ values of 0.25, 2, and 2 mcg/mL, respectively. Ceftobiprole has also demonstrated potent in vitro activity against several clinical isolates of community-associated Methicillin-resistant S. aureus (CA-MRSA), S. aureus (VISA), and S. aureus (VRSA), with a minimum inhibitory concentration (MIC) of 2 mcg/mL.
Ceftobiprole is highly active against S. aureus, withMICs ranging from 0.12 to 4 mg/L (only one resistant strain,MIC of 4 mg/L). Furthermore, Ceftobiprole is twice more active on Methicillin-susceptible S. aureus (MSSA) strains with MIC₅₀ and MIC₉₀ of 0.5 mg/L than on MRSA strains with MIC₅₀ and MIC₉₀ of 1 mg/L. Moreover, Panton-Valentine leukocidin (PVL)+MRSA are slightly more susceptible to Ceftobiprole (MIC₅₀ of 0.5 mg/L and MIC₉₀ of 1 mg/L) than PVL-MRSA (MIC₅₀ and MIC₉₀ of 1 mg/L).

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