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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
GSK656; GSK3036656; GSK070
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2131798-13-3
- 规格：
1 mg/5 mg/10 mg
| 规格： | 1 mg | 产品价格： | ￥2200.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥5500.0 |
| 规格： | 10 mg | 产品价格： | ￥8500.0 |
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Ganfeborole hydrochloride
CAS No. : 2131798-13-3
MCE 国际站：Ganfeborole hydrochloride
产品活性：Ganfeborole hydrochloride (GSK656) 是一种抗结核剂，为结核杆菌亮氨酰-tRNA 合成酶 (leucyl-tRNA synthetase (LeuRS)) 抑制剂，IC50 值为 0.2 μM。
研究领域：Anti-infection
作用靶点：Bacterial
In Vitro: Ganfeborole hydrochloride is highly selective inhibitor for Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS), with an IC50 of 0.2 μM, and shows IC50s of >300 μM and 132 μM for human mitochondrial LeuRS and human cytoplasmic LeuRS, respectively. Ganfeborole hydrochloride exhibits antitubercular activity with minimal inhibitory concentration (MIC) of 80 nM against Mtb H37Rv. Ganfeborole hydrochloride also exhibits EC50s of 381 μM against HepG2 cell, and 137 μM against HepG2 protein synthesis.
In Vivo: Ganfeborole hydrochloride shows potent antitubercular activity in mice infected with M. tuberculosis H37Rv, with ED99 of 0.4 mg/kg.
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