S55746,1448525-91-4

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S55746 hydrochloride

CAS No. : 1448525-91-4

MCE 国际站：S55746 hydrochloride

产品活性：S55746 hydrochloride (BCL201 hydrochloride) 是一种有效、可口服、选择性的 BCL-2 抑制剂，其 K_i 值和 K_d 值分别为 1.3 nM 和 3.9 nM。S55746 hydrochloride (BCL201 hydrochloride) 具有抗肿瘤活性且毒性低。

研究领域：Apoptosis

作用靶点：Bcl-2 Family

In Vitro: S55746 (0-1 μM) potently and selectively induces cell death.
S55746 selectively induces apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner.

In Vivo: S55746 is a highly efficacious and well-tolerated (even at doses up to 300 mg/kg) orally active BCL-2 inhibitor .
S55746 (20-100 mg/kg, p.o.) inhibits xenograft growth in RS4;11 and Toledo models time- and dose-dependently.

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