HS-1371,2158197-70-5

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HS-1371

CAS No. : 2158197-70-5

MCE 国际站：HS-1371

产品活性：HS-1371是高效，ATP-competitive的受体相互作用蛋白3 (RIP3)抑制剂，IC₅₀ 为 20.8 nM。

研究领域：Apoptosis

作用靶点：RIP kinase

In Vitro: HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner. HS-1371 has an inhibitory effect on RIP3 kinase activity in various cell lines.

HS-1371 (0.1, 1, 5, 10, 20 μM, 9 h) can block RIP3 S227 phosphorylation.

HS-1371 (0.1, 1, 5, 10 μM, 24 h) rescues cells from RIP3-dependent necroptotic cell death but not apoptotic cell death.

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