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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2449093-46-1
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥4580.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1600.0 |
| 规格： | 5 mg | 产品价格： | ￥4000.0 |
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LV-320
CAS No. : 2449093-46-1
MCE 国际站：LV-320
产品活性：LV-320 是一种有效且非竞争性的 ATG4B 抑制剂，其 IC50 值为 24.5 μM，Kd 值为 16 μM。 LV-320 抑制 ATG4B 的酶促活性，阻断细胞自噬，并且在体内稳定，无毒且有活性。
研究领域：Autophagy | Metabolic Enzyme/Protease
作用靶点：Atg4 | Autophagy | Cathepsin
In Vitro: LV-320 (0-120 µM; SKBR3, MCF7, JIMT1, and MDA-MB-231 cells) treatment results in a dose-dependent increase in endogenous LC3B-II and protein p62 levels in all four cell lines.
LV-320 (120 µM; 48 hours; MDA-MB-231 cells) treatment results in an increase in LC3B-II, indicating that LV-320 blocks autophagic flux.
In Vivo: LV-320 (100-200 mg/kg; oral gavage; three times over two days; GFP-LC3 mice) treatment results in a terminal blood level of 169 µM and a liver level of 104 µM. The expression of GFP-LC3 puncta is significantly greater accumulation in LV-320 treated animals compared to controls. LC3B-II protein is also increased in LV-320-treated animals. The treatment do not cause significant toxicity in mice at either dose.
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文献和实验cytosine mixture prior to beginning the LOH reaction setup. Vortex all reagents, with the exception of Taq Gold Polymerase before beginning the PCR reaction setup. Prepare 320 µl reduced nucleotide mixture: Aliquot 1 µl of each DNA sample
the LOH reaction setup. Vortex all reagents, with the exception of Taq Gold Polymerase before beginning the PCR reaction setup. Prepare 320 µl reduced nucleotide mixture:
High‐Throughput Cytotoxicity Screening by Propidium Iodide Staining
384‐well polypropylene, shallow profile, conical‐bottom microplates (Greiner): sterilized for at least 10 hr under a 253.7‐nm germicidal lamp in a biological safety cabinet; 3 plates/320 wells of test compounds
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