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- 保存条件：
Pure form: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
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MedChemExpress LLC
- CAS号：
2088939-99-3
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1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 1 mg | 产品价格： | ￥659.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1450.0 |
| 规格： | 10 mg | 产品价格： | ￥1950.0 |
| 规格： | 25 mg | 产品价格： | ￥3120.0 |
| 规格： | 50 mg | 产品价格： | ￥4160.0 |
| 规格： | 100 mg | 产品价格： | ￥5400.0 |
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LYN-1604
CAS No. : 2088939-99-3
MCE 国际站：LYN-1604
产品活性：LYN-1604 是一种有效的 UNC-51 样激酶 1 (ULK1) 激活剂，EC50 值为 18.94 nM。LYN-1604 可用于三阴性乳腺癌 (TNBC) 的研究。
作用靶点：ULK | Autophagy | Apoptosis
In Vitro: LYN-1604 is a potential ULK1 agonist (enzymatic activity=195.7% at 100 nM and IC50=1.66 μM against MDA-MB-231 cells) .
LYN-1604 binds to wild-type ULK1 with a binding affinity in the nanomole range (KD=291.4 nM) .
LYN-1604 (0.5, 1.0 and 2.0 μM) induces cell death via the ULK complex in MDA-MB-231 cells.
LYN-1604 (0.5-2 μM, 24 hours) induces remarkable up-regulation of Beclin-1 and degradation of p62, as well as transformation of LC3-I to LC3-II in MDA-MB-231 cells.
LYN-1604 induces ATG5-dependent autophagy via the ULK complex.
LYN-1604 can also increase cleavage of caspase3 and induce apoptosis.
In Vivo: LYN-1604 (low dose, 25 mg/kg; median dose, 50 mg/kg; high dose, 100 mg/kg; intragastric administration once a day for 14 days) inhibits the growth of xenograft TNBC by targeting ULK1-modulated cell death.
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文献和实验'Haeseleer P, Wen X, Fuhrman S., Somogyi R. 1999. Linear modeling of mRNA expression levels during CNS development and injury. Pacific Symp. Biocomp. 99, 4152. 29• Datta S. 2003. Comparisons and validation of statistical clustering techniques
were from Sigma Chemical Co.2.2.Treatment solutionsClivorine isolated from L. hodgsonii was structurally elucidated by IR, NMR, MS spectra and its purity determined by HPLC was 99.5%. The structure of clivorine is shown in Fig. 1. The roots and rhizomes of L
): Conc. Stock 1L 1.5L 2.0L 2.5L Tris base 1.78M 121.14g/M 216g 324g 432g 540g Taurine 0.56M 125.15g/M 72g 108g 144g 180g Na2 EDTAx2H2 O 10.7mM 372.3 g/M 4g 6g 8g 10g H2 O mQ 802ml 1203ml 1604ml
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