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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Trifluorothymidine; 5-Trifluorothymidine; TFT
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
70-00-8
- 规格：
10 mM * 1 mL/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥169.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥154.0 |
| 规格： | 100 mg | 产品价格： | ￥269.0 |
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Trifluridine
CAS No. : 70-00-8
MCE 国际站：Trifluridine
产品活性：Trifluridine (Trifluorothymidine) 是一种不可逆的、具有口服活性的胸苷酸合酶 (thymidylate synthase) 抑制剂，从而抑制 DNA 合成。Trifluridine 是一种抗病毒活性分子，可用于疱疹病毒 (HSV)、横纹肌病毒和正痘病毒 (orthopoxvirus) 的研究。Trifluridine 诱导细胞凋亡 (apoptosisautophagy)。Trifluridine 也是一种抗癌剂，用于转移性结直肠癌、胃肠道肿瘤的研究。
研究领域：Apoptosis | Anti-infection | Cell Cycle/DNA Damage | Autophagy
作用靶点：Thymidylate Synthase | HSV | Nucleoside Antimetabolite/Analog | Orthopoxvirus | DNA/RNA Synthesis | Apoptosis | Autophagy
In Vitro: Trifluridine (0.5 μΜ, 3 days) induces cellular senescence in HUVECs.
Trifluridine (0.5 μΜ, 3 days) inhibits autophagy and autophagy flux via the mTOR pathway in HUVECs .
Trifluridine (0-5 μΜ, 3 days) inhibits HUVEC cells viability in a concentration-dependent way.
Trifluridine (5 µM-20 µM, 24 h–72 h) inhibits the proliferation in MCF-7, MDA-MB-231, BT-549 and Hs578T.
Trifluridine (0 µM-20 µM, 48 h) selectively induces apoptosis in MCF-7, MDA-MB-231, BT-549 and Hs578T cells .
Trifluridine (10 µM, 72 h) induces DNA double-strand break in MCF-10A, MCF-7, MDA-MB-231 and BT-549 cells.
In Vivo: Trifluridine/tipiracil (200 mg/kg, PO, twice daily for 5 consecutive days followed by 2 drug‑free days for 6 weeks) shows antitumor activity in the human colorectal intraperitoneal xenograft model.
Trifluridine (75 or 150 mg/kg, oral gavage, once daily for 5 consecutive days) inhibits the growth in implanted mouse TNBC tumors .
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文献和实验3.82 3.47 3.25 3.09 2.97 2.87 2.80 2.73 2.64 2.53 2.42 2.31 2.18 2.04 21 22 4.38 3.73 3.44 3.21 3.05 2.93 2.84 2.76 2.70 2.60 2.50 2.39 2.27 2.14 2.00 22 23 4.35 3.75 3.41 3.18 3.02 2.90 2.81 2.73 2.67 2.57 2.47 2.36 2.24 2.11 1.97 23 24
倍数1000120015001800200025003000350040001：100溶血素0.100.100.100.100.100.100.100.100.10生理盐水0.901.101.401.701.902.402.903.403.90全量1.001.201.501.802.002.503.003.504.00另取小反应管一列，按次序从每一稀释液取0.50ml分别加入各管中，添加时应由稀释度大的稀释液加起，这样可不必更换吸管。然后再加入生理盐水1.00ml，1︰20补体和2.50％红细胞悬液各0.50ml。在37℃水浴槽中放20min后判定结果。详细造作程序见表
(20X) EnhanceIT Polymer solution (10X) TEMED Ammonium Persulfate 12% 50-150 3.00 ml 5.5 ml 0.50 ml 1.00 ml 5 µl 50 µl 11% 60-200 2.75 ml 5.75 ml 0.50 ml 1.00 ml 5 µl 50 µl 10% 70-250 2.50 ml 6.00 ml 0.50 ml 1.00 ml 5 µl 50 µl
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