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- 2025年12月05日
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- 详细信息
- 询价记录
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
CX-4945
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1009820-21-6
- 规格：
10 mM * 1 mL/2 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1250.0 |
|---|---|---|---|
| 规格： | 2 mg | 产品价格： | ￥650.0 |
| 规格： | 5 mg | 产品价格： | ￥1000.0 |
| 规格： | 10 mg | 产品价格： | ￥1600.0 |
| 规格： | 25 mg | 产品价格： | ￥2980.0 |
| 规格： | 50 mg | 产品价格： | ￥4500.0 |
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Silmitasertib
CAS No. : 1009820-21-6
MCE 国际站：Silmitasertib
产品活性：Silmitasertib (CX-4945) 是一种有效、可口服、高度选择性的 CK2 抑制剂，对 CK2α 和 CK2α' 的 IC50值均为 1 nM。
研究领域：Cell Cycle/DNA Damage | Stem Cell/Wnt | Autophagy
作用靶点：Casein Kinase | Autophagy
In Vitro: Silmitasertib (CX-4945) causes cell-cycle arrest and selectively induces apoptosis in cancer cells relative to normal cells, attenuates PI3K/Akt signalingand, and the antiproliferative activity of Silmitasertib (CX-4945) is correlated with expression levels of the CK2α catalytic subunit, Attenuation of PI3K/Akt signaling. Silmitasertib (CX-4945) with PS-341 treatment prevents leukemic cells from engaging a functional UPR in order to buffer the PS-341-mediated proteotoxic stress in ER lumen, and decreases pro-survival ER chaperon BIP/Grp78 expression. Silmitasertib (CX-4945) induces cytotoxicity and apoptosis, and exerts anti-proliferative effects in hematological tumors by downregulating CK2 expression and suppressing activation of CK2-mediated PI3K/Akt/mTOR signaling pathways.
In Vivo: Silmitasertib (CX-4945) (25 or 75 mg/kg, p.o.) is well tolerated and demonstrated robust antitumor activity with concomitant reductions of the mechanism-based biomarker phospho-p21 (T145) in murine xenograft models.
相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Kinase Inhibitor Library | Stem Cell Signaling Compound Library | Wnt/Hedgehog/Notch Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Antiviral Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | Endoplasmic Reticulum Stress Compound Library | Orally Active Compound Library | Targeted Diversity Library | Rare Diseases Drug Library | Human Metabolite Library | Non-steroidal Anti-Inflammatory Compound Library | Cancer Stem Cells Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Cell Death Library | Serine/Threonine Kinase Inhibitor Library | LY294002 | IWP-2 | Emodin | Ellagic acid | D4476 | Umbralisib | PF-670462 dihydrochloride | TBB | Silmitasertib sodium salt | TMX-4116 | Casein Kinase inhibitor A51 | DMAT | PF-4800567 | (E/Z)-GO289 | SR-3029 | SSTC3 | IC261 | TAK-715 | FPFT-2216 | CKI-7 free base | SGC-CK2-1 | CK1-IN-1 | TTP 22 | BTX161 | AMG-548 dihydrochloride | BioE-1115 | Hematein | TA-01 | MRT00033659 | CK2/ERK8-IN-1
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