- ￥395 - 2550
- MedChemExpress(MCE)
- 美国
- HY-16560
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, protect from light
- 英文名：
Campathecin; (S)-(+)-Camptothecin; CPT
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
7689-03-4
- 规格：
10 mM * 1 mL/100 mg/500 mg/1 g/5 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥500.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥395.0 |
| 规格： | 500 mg | 产品价格： | ￥900.0 |
| 规格： | 1 g | 产品价格： | ￥1280.0 |
| 规格： | 5 g | 产品价格： | ￥2550.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Camptothecin
CAS No. : 7689-03-4
MCE 国际站：Camptothecin
产品活性：Camptothecin (CPT)，一种生物碱，是一种 DNA topoisomerase I (Topo I) 抑制剂，其 IC50 值为 679 nM。Camptothecin (CPT) 对结直肠癌、乳腺癌、肺癌和卵巢癌具有强大的抗肿瘤活性，通过改变人类癌细胞中的 miRNA 表达模式来调节 hypoxia-inducible factor-1α (HIF-1α) 活性。
研究领域：Cell Cycle/DNA Damage | Antibody-drug Conjugate/ADC Related | Epigenetics | Apoptosis | Anti-infection
作用靶点：Topoisomerase | ADC Cytotoxin | MicroRNA | Influenza Virus | Apoptosis | Fungal | Antibiotic
In Vitro: High TOP1 enzymatic activity MCF7 (Luminal subtype) and HCC1419 (HER2 subtype) show high sensitivity toward Camptothecin (0.1 μM to 5 μM; 72 hours) treatment, exhibiting the IC50 values of 0.089 μM and 0.067 μM, respectively.
Camptothecin (0.5 μM; 6 and 24 hours) reduces desferrioxamine-activated VEGF expression.
Camptothecin (0.5 μM; 8 to 24 hours) strongly prevents the desferrioxamine-dependent HIF-1a accumulation.
In Vivo: Camptothecin (2 mg/kg every other day) treats mice, has developed numerous pulmonary metastases.
Treatment with both kinase inhibitor of nuclear factor-kappaB-1 (KINK-1) and Camptothecin led to a statistically significant reduction in the number of pulmonary metastases.
相关产品：Natural Product Library Plus | Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Anti-Infection Compound Library | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Natural Product Library | FDA-Approved Drug Library | Toxins for Antibody-Drug Conjugate Research Library | Anti-Cancer Compound Library | Antiviral Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Antifungal Compound Library | NMPA-Approved Drug Library | Traditional Chinese Medicine Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Antibiotics Library | Alkaloids Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Targeted Diversity Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Natural Product Library | Chemotherapy Drug Library | Antiviral Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | FDA-Approved Anticancer Drug Library | Anti-Prostate Cancer Compound Library | Heterocyclic Compound Library | Off-patent Drug Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Cell Death Library | FDA-Approved Traditional Chinese Medicine Active Compound Library | MG-132 | Ferrostatin-1 | Rapamycin | Cycloheximide | Chloroquine | Doxorubicin hydrochloride | Bafilomycin A1 | LY294002 | Tamoxifen | Paclitaxel | Y-27632 | Dexamethasone | Acetylcysteine | Puromycin dihydrochloride | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | SB-431542 | Actinomycin D | Deferoxamine mesylate | Bortezomib | 5-Fluorouracil | Trametinib | Sorafenib | Oxaliplatin | Gemcitabine | G-418 disulfate | Temozolomide | Rotenone | Mdivi-1
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验示例： Jurkat细胞用1μM喜树碱(Camptothecin) (左)或未加药 (右)处理4h，FITC-Annexin V/PI荧光双染细胞凋亡检测试剂盒染色后，流式细胞仪荧光检测。 Annexin V-FITC单阳性细胞为早期凋亡细胞，Annexin V-FITC和PI染色双阳性的细胞为坏死细胞或者晚期凋亡。PI单染色阳性位裸核细胞。 实测数据可能会因细胞类型、细胞凋亡情况，检测仪器等的不同而存在差异，图中数据仅供参考。 流式检测细胞凋亡的数据分析方法： 1） 选中所有颗粒，将FSC
iodide (P1304, P3566, P21493). The image was acquired using bandpass filters appropriate for fluorescein. Jurkat 人类白血病T细胞经1微升喜树碱处理，ps外翻，早期凋亡特异性的特征被annexin－5检测到。晚期凋亡和坏死细胞被pi染色。本图是由相应的荧光滤光片获取的。 HL-60 cells treated with camptothecin for three hours
重组人TFAR19蛋白对羟基喜树碱诱导人7721肝癌细胞凋亡的增敏作用
新的人凋亡相关基因产物TFAR19 蛋白对羟基喜树碱诱导人7721 肝癌细胞凋亡的增敏作用。 方法:将不同浓度的rhTFAR19 蛋白单独或与羟基喜树碱(hydroxy camptothecin , HCPT) 同时加入处于指数生长期的7721 肝癌细胞中共同培养,通过透射电镜、DNA 片段化分析、PI 及Annexin V 标记进行流式细胞仪分析,观察细胞的形态学和细胞凋亡的变化。 结果:不同质量浓度的rhTFAR19 蛋白单独作用于7721 肝癌细胞未见明显
技术资料暂无技术资料 索取技术资料
