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Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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MedChemExpress LLC
- CAS号：
265129-71-3
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10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1327.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1200.0 |
| 规格： | 10 mg | 产品价格： | ￥1800.0 |
| 规格： | 25 mg | 产品价格： | ￥3600.0 |
| 规格： | 50 mg | 产品价格： | ￥5700.0 |
| 规格： | 100 mg | 产品价格： | ￥9100.0 |
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GW7647
CAS No. : 265129-71-3
MCE 国际站：GW7647
产品活性：GW7647 是一种有效的 PPARα 激动剂，对人 PPARα,PPARγ 和 PPARδ 的 EC50 值分别为 6 nM, 1.1 μM 和 6.2 μM。
研究领域：Cell Cycle/DNA Damage | Vitamin D Related/Nuclear Receptor
作用靶点：PPAR
In Vitro: GW7647 (1 μM) causes a significant increase of PDZK1 protein expression to 129.7 ± 6.5% of vehicle treated control in Caco2BBE cells in the absence and presence of IL-1β. GW7647 also attenuates the IL-1β-mediated decrease in PDZK1 expression.
GW7647 (50 nM) stimulates the PI3K phosphorylation followed by the Akt (Ser473) phosphorylation, which induces NOS1 phosphorylation increased the amounts of NO released in the stripped antral mucosa. GW7647 (50 nM) enhances the initial phase of Ca2+-regulated exocytotic events stimulated by ACh in antral mucous cells, but GW7647 alone does not evoke any exocytotic event. GW7647 plus ACh stimulates the effects of wortmannin (50 nM) and AKT-inh (100 nM) on the exocytotic events in antral mucous cells.
GW 7647 (100 nM) reduces the AQP9 protein abundance by 43%, but it shows not significant effect at 10 and 1,000 nM in WIF-B9 hepatocytes. GW 7647 (100 nM) causes a 24% reduction in AQP9 protein abundance in HepG2 cells, however, it does not significantly increase the protein abundance of L-FABP in HepG2 hepatocytes.
In Vivo: GW7647 (3 mg/kg per day) does not prevent the development of cardiac hypertrophy, but it prevents the decline in left ventricular ejection fraction in vivo.
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文献和实验magichunter 我在文献中查到，PPARr拮抗剂GW9662可以抑制药物的抗炎作用，前提是药物是通过激活PPARr来实现其抗炎作用的。即炎症细胞中的炎症因子（如：NO）升高，加入抗炎药物后，NO水平降低，当同时给予GW9662和该抗炎药物时，该药物的抗炎作用被抑制，NO水平再次升高。以上是文献的报道，但是我在实验时发现，加入了抗炎药物+GW9662后，NO的水平不但没有升高，反而降低了（与单独抗炎药物组相比），不知这是怎么回事？ chp
. A new drug candidate belonging to the family of the peroxisome proliferator-activated receptor-delta agonists termed GW1516 (also referred to as GW501516) has been prohibited by the World Anti-Doping Agency in 2009
可促进 PPARα的表达，而沉默 HLF 可抑制其表达。而后作者利用 PPARα抑制剂 GW6471 研究 PPARα是否参与了小鼠 MAFLD 模型中 HLF 的调控，结果发现与对照组小鼠相比，GW6471 处理小鼠肝脏中 TG 和总胆固醇（TC）水平较低，抑制 PPARα可减轻脂质沉积和 HFD 引起的肝损以及改善小鼠肠道屏障功能。随后收集粪便进行 16S rDNA 测序，评估肠道微生物群的变化。结果发现 HLF 通过抑制 PPARα信号通路，降低氧化应激，改善肠道微生物群的稳态，从而缓解
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