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- MedChemExpress(MCE)
- 美国
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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
108409-83-2
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥614.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥174.0 |
| 规格： | 5 mg | 产品价格： | ￥348.0 |
| 规格： | 10 mg | 产品价格： | ￥558.0 |
| 规格： | 50 mg | 产品价格： | ￥1640.0 |
| 规格： | 100 mg | 产品价格： | ￥2625.0 |
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FH535
CAS No. : 108409-83-2
MCE 国际站：FH535
产品活性：FH535 是 Wnt/β-catenin 和 PPAR 的抑制剂，具有抗肿瘤活性。
研究领域：Cell Cycle/DNA Damage | Vitamin D Related/Nuclear Receptor | Stem Cell/Wnt
In Vitro: FH535 is an inhibitor of Wnt/β-catenin and PPAR. FH535 inhibits PPARγ and PPARδ transactivation in HCT116 cells. FH535 (15 μM) activities depend on functional PPARδ but does not require a cysteine residue in the PPAR ligand-binding domain. FH535 inhibits recruitment of the coactivators GRIP1 and β-catenin to PPARδ and PPARγ. FH535 shows toxic effects on 12 carcinoma cell lines expressing wnt/β-catenin pathway.
FH535 (20 μM) suppresses the β-catenin pathway in pancreatic cancer cells, and inhibits pancreatic cancer cell migration. Furthermore, FH535 (20, 40 μM) inhibits pancreatic cancer cell invasion and cell growth.
FH535 represses angiogenesis-related genes in pancreatic cancer cells.
In Vivo: FH535 (25 mg/kg, i.p.) exhibits an anti-tumor effect on pancreatic cancer xenografts in mice. FH535 also represses angiogenesis in pancreatic cancer xenografts.
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