- ￥485 - 2361
- 爱必信(absin)
- 上海
- abs810355
- 2025年07月15日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 保质期：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 英文名：
FH 535; FH-535
- 库存：
现货
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
108409-83-2
- 规格：
50mg/5mg
| 规格： | 50mg | 产品价格： | ￥2361.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥485.0 |
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抑制剂描述： 产品名称：FH535 产品别名：见爱必信官网 英文别名：FH535 靶点：Wnt;PPAR;β-catenin CAS：108409-83-2 纯度：98% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述： FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling. 溶解性：DMSO ：72mg/ml(199.34 mM) 体外研究： FH535 antagonizes β-Catenin/Tcf–mediated transcription, and inhibits recruitment of the coactivators GRIP1 and β-catenin to PPARδ and PPARγ. FH535 shows selective anti-proliferation effect on some cancer cells expressing high or active Wnt/β-catenin pathway. FH535 increases cigarette smoke condensate cytotoxicity, and causes changes in β-catenin and EGR-1 signaling. FH535 has potential therapeutic value in treatment of liver cancer by targeting liver cancer stem cells and hepatocellular carcinoma cell lines. 体内研究：FH535 (25 mg/kg, i.p.) exhibits an anti-tumor effect on pancreatic cancer xenografts in mice. FH535 also represses angiogenesis in pancreatic cancer xenografts.
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Research square.
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