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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1400284-80-1
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥5540.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥2000.0 |
| 规格： | 5 mg | 产品价格： | ￥5000.0 |
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CCT251455
CAS No. : 1400284-80-1
MCE 国际站：CCT251455
产品活性：CCT251455是有效和选择性的有丝分裂激酶单极纺锤体1 (MPS1) 抑制剂，IC50 值为3 nM。
研究领域：Cell Cycle/DNA Damage | Cytoskeleton
作用靶点：Mps1
In Vitro: CCT251455 is a highly potent inhibitor of MPS1 that demonstrates high selectivity versus kinases tested in a broad kinome profiling panel. CCT251455 inhibits P-MPS1 with an IC50 of 0.04 μM in cell-based assay and has a GI50 of 0.16 μM.
In Vivo: CCT251455 demonstrates a good oral pharmacokinetic profile in mouse and rat as well as inhibition of MPS1 activity in vivo following oral administration.
相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Kinase Inhibitor Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Cytoskeleton Compound Library | Highly Selective Inhibitors Library | BAY1217389 | AZ3146 | NMS-P715 | MPI-0479605 | BOS-172722 | Empesertib | Mps1-IN-1 | Mps1-IN-2 | Mps1-IN-3 | Mps-BAY2a | Mps1-IN-7 | TC-Mps1-12 | Mps1-IN-1 dihydrochloride | Mps1-IN-4 | Mps1-IN-5 | Mps1-IN-6 | RMS-07
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文献和实验Inverse PCR & Cycle Sequencing
I. Quick Fly Genomic DNA Prep Standard fly mini prep (30 flies) resuspended in 150 ul TE 1) Collect 30 anesthetized flies in eppendorf tube and freeze at -80°. 2) Grind flies in 200 µl Buffer
Inverse PCR Cycle Sequencing of P Element Insertions for STS Generation
I. Quick Fly Genomic DNA Prep Standard fly mini prep (30 flies) resuspended in 150 ul TE 1) Collect 30 anesthetized flies in eppendorf tube and freeze at -80°. 2) Grind flies in 200 µl Buffer A with disposable tissue
GGG CGG WGT GTA CAA GGC Marchesi et al. 1998 778R AGG GTA TCT AAT CCT GTT TGC Rosch & Bothe
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