AZD1390,2089288-03-7

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AZD1390

CAS No. : 2089288-03-7

MCE 国际站：AZD1390

产品活性：AZD1390 是一种有效的，高度选择性的，口服生物利用的，可渗透脑的 ATM 抑制剂，在细胞中对 ATM 的 IC₅₀ 为 0.78 nM。

研究领域：Cell Cycle/DNA Damage  |  PI3K/Akt/mTOR

作用靶点：ATM/ATR

In Vivo: Median survival of mice treated with AZD1390 and radiation are significantly longer than untreated control mice (p=0.001). No overt signs of treatment toxicity are observed with small animal radiation research platform (SARRP) contrary to wholehead irradiated mice that seem to develop mucositis and difficulties drinking and eating at doses >10 Gy in combination with AZD1390.

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