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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
200626-61-5
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥312.0 |
| 规格： | 10 mg | 产品价格： | ￥500.0 |
| 规格： | 25 mg | 产品价格： | ￥850.0 |
| 规格： | 50 mg | 产品价格： | ￥1300.0 |
| 规格： | 100 mg | 产品价格： | ￥2200.0 |
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ITSA-1
CAS No. : 200626-61-5
MCE 国际站：ITSA-1
产品活性：ITSA-1 是 HDAC 的激活剂，可抵消曲古抑菌素 A (trichostatin A, TSA) 诱导的细胞周期停滞，组蛋白乙酰化和转录水平的激活。
研究领域：Cell Cycle/DNA Damage | Epigenetics
作用靶点：HDAC
In Vitro: ITSA-1 (50 μM; A549 cells) treatment serves to revert the TSA-arrested population to a normal cell cycle distribution. ITSA-1 is also able to effect cell cycle rescue over longer duration.
?ITSA-1 (50 μM; 5 hours; A549 cells) treatment reduces the number of apoptosis in TSA-treated cells.
?ITSA-1 (50 μM; 2 hours; A549 and murine ES cells cells) treatment suppresses TSA-induced histone acetylation. Importantly, suppression of acetylation levels is only observable when ITSA1 is added concurrent with or post TSA treatment.
?ITSA-1 (50 μM; 30 minutes; murine ES cells cells) suppresses TSA-activated transcription in murine ES cells.
In Vivo: ITSA-1 (0.5 mg/kg; intraperitoneal injection; 3 times/week; for 8 weeks; CBS+/? mice) balances deacetylation activity and suppresses IL-6 and TNF-α expression and thereby attenuated histone acetylationdependent infammatory signaling.
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文献和实验动物种类 肠 道 长 度 单位 全长 小肠 盲肠 大肠 狗 m 2.2-5
TP g/L 56.65±4.80 276 61.0-78
.4 4-5 家兔 1-2 5.6(4.3-7.0) 66.8±7.962.559.0-62.8 6.7±2.310.7a1 2.9-5.4a2 6.3-7.6 9.6±3.214.814.1-19.1 16.8±6.812.010.2-11
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