ITSA-1 ,200626-61-5

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抑制剂描述：

产品名称：ITSA-1

产品别名：见爱必信官网

英文别名：ITSA-1

靶点：HDAC

CAS：200626-61-5

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

描述：

ITSA-1 (ITSA1) is an <b>HDAC</b> activator via TSA suppression, but shows no activity towards other HDAC inhibitors.

溶解性：DMSO : 54 mg/mL (184.9 mM)
Ethanol : 5 mg/mL (17.12 mM)

体外研究：

ITSA1 (50 μM; A549 cells) treatment serves to revert the TSA-arrested population to a normal cell cycle distribution. ITSA1 is also able to effect cell cycle rescue over longer duration.
ITSA1 (50 μM; 5 hours; A549 cells) treatment reduces the number of apoptosis in TSA-treated cells.
ITSA1 (50 μM; 2 hours; A549 and murine ES cells cells) treatment suppresses TSA-induced histone acetylation. Importantly, suppression of acetylation levels is only observable when ITSA1 is added concurrent with or post TSA treatment.
ITSA1 (50 μM; 30 minutes; murine ES cells cells) suppresses TSA-activated transcription in murine ES cells.

体内研究：ITSA-1 (0.5 mg/kg; intraperitoneal injection; 3 times/week; for 8 weeks; CBS+/− mice) treatment balances deacetylation activity and suppresses IL-6 and TNF-α expression and thereby attenuated histone acetylationdependent infammatory signaling.

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