- ￥990 - 4050
- MedChemExpress(MCE)
- 美国
- HY-108435
- 2025年12月05日
企业认证
相关产品推荐更多 >
![(S)-2-((3S,5aS,9aS,10aS)-3-Methyl-1,4-dioxodecahydropyrazino[1,2-a]indol-2(1H)-yl)pentanoic acid (Perindopril Impurity) (Standard)培哚普利EP杂质C (标准品),129970-99-6](https://img1.dxycdn.com/p/s14/2025/1205/984/8081510498539586991.jpg!wh200)
(S)-2-((3S,5aS,9aS,10aS)-3-Methyl-1,4-dioxodecahydropyrazino[1,2-a]indol-2(1H)-yl)pentanoic acid (Perindopril Impurity) (Standard)培哚普利EP杂质C (标准品),129970-99-6
询价
5-n-Heptyl-6-hydroxy-4,7-dioxobenzothiazole,611207-02-4
询价
Di(thiophen-2-yl)methanone (Standard)双(2-噻吩)酮 (标准品),704-38-1
询价
Benzaldehyde diethyl acetal-d10
询价
LY 97241,72456-63-4
询价
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C, stored under nitrogen
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1936421-41-8
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1112.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥990.0 |
| 规格： | 10 mg | 产品价格： | ￥1585.0 |
| 规格： | 25 mg | 产品价格： | ￥2395.0 |
| 规格： | 50 mg | 产品价格： | ￥4050.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
GNE-049
CAS No. : 1936421-41-8
MCE 国际站：GNE-049
产品活性：GNE-049 是一种高效的选择性 CBP 抑制剂，在 TR-FRET 实验中 IC50 为 1.1 nM。GNE-049 还抑制 BRET 和 BRD4(1)，IC50 分别为 12 nM 和 4200 nM。
研究领域：Epigenetics
作用靶点：Epigenetic Reader Domain | Histone Acetyltransferase
In Vitro: GNE-049 is selected for further profiling as it has the best balance of liver microsomes (LM) stability, selectivity, and cellular potency GNE-049 has excellent potency in the BRET cellular assay and, in an orthogonal measure of the target engagement, GNE-049 is shown to inhibit the expression of MYC (MV4-11 cell line) with an EC50 of 14 nM.
In Vivo: GNE-049 demonstrates acceptable PK in mouse, rat, dog, and monkey. Determination of potency versus a selection of bromodomains revealed that GNE-049 is selective for CBP/P300 and, importantly, quite selective (3820-fold) over BRD4(1). GNE-049 is further evaluated in a rat single dose (30-250 mg/kg QD) toxicokinetic study. Adverse central nervous system (CNS)-related signs (e.g., marked hyperactivity and vocalization) are observed in several of the rats at the 250 mg/kg dose level. Furthermore, at the 250 mg/kg dose level, the ratio of the unbound drug concentration in brain to unbound drug concentration in plasma (Kp,uu) 3 h post dose is determined to be 0.43, indicating that GNE-049 is penetrating into the CNS and potentially resulting in the observed toxicity.
相关产品：Covalent Screening Library Plus | Bioactive Compound Library Plus | Epigenetics Compound Library | Histone Modification Research Compound Library | Anti-Cancer Compound Library | CNS-Penetrant Compound Library | Covalent Screening Library | Reprogramming Compound Library | Chemical Probe Library | Anti-Blood Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Highly Selective Inhibitors Library | (+)-JQ-1 | Curcumin | Acetaminophen | A-485 | C646 | Revumenib | BRM/BRG1 ATP Inhibitor-1 | BI 2536 | dBET6 | MZ 1 | ARV-825 | Inobrodib | Birabresib | Remodelin hydrobromide | 666-15 | SGC-CBP30 | VTP50469 | ACBI1 | WM-3835 | AU-15330 | PF-9363 | ARV-771 | I-BET151 | dBET1 | dCBP-1 | ABBV-744 | Anacardic Acid | Molibresib | NSC 228155
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验滑膜组织凝胶图谱的平均蛋白质点数分别为1 070±41、1 049±22、1 079±44和1 088±39。在4个组均有表达差异的蛋白质点中随机取20个点进行肽质指纹图分析，鉴定了部分与细胞代谢、信号转导及结构相关的差异表达蛋白质。结论：建立了分辨率较高且重复性较好的正常大鼠与CIA大鼠不同时间点滑膜组织的双向凝胶电泳图谱，鉴定了一些与CIA大鼠滑膜病变相关的差异表达蛋白质，为识别RA病变相关蛋白质及推断RA病变过程奠定基础。
【共享】Methods in molecular biology 下载
and Applications http://rapidshare.com/files/10750768/015-PCR_Protocols__1st_Edition.pdf http://ec1.images-amazon.com/images/I/41SCA8GTPXL.jpg Vol 16 Enzymes of Molecular Biology http://rapidshare.com/files/9844513/016-Enzymes_of_molecular_biology__1993_MMB
785.2 H2 O [ml] 948.35 895 840.65 784.6 727.15 668.2 607.55 545.7 %(w/w) 9.379 17.988 25.940 33.350 40.295 46.846 53.070 58.998 H2 O %(w/w) 90.621 82.012 74.060 66.650 59.705 53.154 46.930 41.002 p (g
技术资料暂无技术资料 索取技术资料
